In this paper, Perkin Elmer GCMS2400 gas chromatography-mass spectrometer was used to accurately determine the content of tetramethylpyrazine in Baijiu by selecting the ion monitoring (SIM) method, which has important significance for the Baijiu industry to continuously explore the impact of various process parameters on the formation of tetramethylpyrazine, optimize its process to increase the content of tetramethylpyrazine and monitor the change of tetramethylpyrazine content throughout the process; At the same time, it can increase the publicity of Chinese Baijiu for its health, change the misunderstanding of consumers that Baijiu has no nutrition, and promote it to the international market, so that consumers in other countries can appreciate and enjoy the beautiful and healthy Chinese Baijiu, increase the value of Baijiu, improve its market, and thus produce certain economic and social benefits.