Inductively coupled plasma mass spectrometry (ICP-MS), as a multi-element detection technology, has the advantages of high sensitivity, flexible sample types (gas, liquid, and solid), fast measurement speed, and wide linear dynamic range.ICP-MS (SP-ICP-MS) operating in single particle mode has been proven to be a powerful technique for detecting and measuring nanoparticles (NPs), capable of determining various nanoparticle characteristics such as inorganic composition, concentration, particle size, particle size distribution, and aggregation.