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Nanjing Jinwei Biotechnology Co., Ltd

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Mechanical troubleshooting of microbial fermentation tanks
Date: 2025-08-18Read: 1
Microbial fermentation tankIt is a core equipment used in the field of biotechnology for microbial cultivation and process optimization. The equipment adopts excellent sealing technology to ensure that the tank body does not leak under high pressure, ensuring the safety and stability of the experiment; Based on ISA-88 self-control architecture and ISA-95 network architecture, it supports batch control of MES and other software to achieve path management; A complete set of GEP/GMP documents from RA to RTM to ensure compliance; Support continuous cell culture for 30 days * 24 hours.
Advantage:
Concise interface: Mastering the operation in hours, achieving twice the result with half the effort.
Unmanned: It can be accessed and operated remotely, achieving unmanned operation.
Formula function: One click distribution of formulas, reducing personnel operational errors and improving quality.
Data analysis: enables comparison of multiple batches of data, and can also be integrated with Doe&PAT for in-depth multivariate analysis to optimize process data.
Data sharing: Based on VPN, web publishing enables monitoring and historical curve viewing on mobile devices (Android, IOS, Windows) while ensuring data and device security.
Summary of operation points:
Preparation period - third level seed amplification, pipeline leak detection - filtration, sterilization, and pollution prevention
Sterilization period -121 ℃ saturated steam penetration - compliant operation of pressure vessels
Operation period - DO/pH linkage regulation, trace feeding - defoamer backup, anti infection bacteria sampling
Closing period - gradient cooling, stability treatment of live bacteria - emergency stop system testing
Fault handling:
Mixing shaft seal leakage - dynamic seal wear/corrosion - replace PTFE graphite composite seal ring.
Valve leakage - gasket aging or loose screws - stop and replace fluororubber gasket+torque wrench reinforcement.
Condenser failure - blocked cooling water pipe/circulation pump failure - chemical cleaning pipeline+backup pump switch.
Sensor reading drift - electrode scaling/signal interference - monthly calibration of pH/DO probe+shielded cable wiring. ‌