In the fields of vaccine production, cell therapy, and even artificial meat, microcarrier based cell culture technology has become a key process for large-scale production. This type of cultivation process usually includes three stages: cell attachment, growth, and detachment. At present, real-time monitoring of cell density (VCD) through capacitive sensors has been widely adopted, which is in line withProcess analysis technologyThe requirements of PAT help optimize and control the production process.

However, real-time monitoring of cell detachment processes has always been a technical challenge. Traditional methods rely on offline sampling and microscopic observation, which are not only cumbersome and have limited accuracy, but also prone to pollution risks, especially in large-scale GMP production.

Recently, Hamilton CorporationIncyteThe successful application of sensors in real-time monitoring of micro carrier cell detachment has brought a new solution to the industry.

• ✅‌Real time prediction of detachment status:No need for offline sampling, reducing pollution risk

• ✅‌Intelligent regulation of enzyme dosage:Intervene promptly when enzyme activity is insufficient

• ✅‌Improve process consistency:Support automated operations to accelerate production pace.

The experimental results confirm that the sensor signal is highly correlated with desorption efficiency and can predict desorption results in advance, which can help upgrade the process intelligence.

Make the process of cell detachment clear at a glance, providing support for vaccine production, cell therapy, and artificial meat research and development.