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Rare blood types
Date: 2025-12-13Read: 1
Rare blood types
If you think your O-type Rh negative (commonly known as "panda blood") is already rare enough, it can only be said that you have not yet seen a true "blood aristocrat". In the microscopic world of human red blood cells, some blood types are even harder to compete for than XIAN sneakers - such as the "golden blood" possessed by only about 50 people（Rhnull）Or "diamond blood" with a probability of less than one in ten thousand among the Chinese population（Jk(a-b-)）。 These names sound likeLike Marvel SuperThe code name of a hero, but for carriers, it may be a health timed explosive DAN that can explode at any time.
Rare blood types: not just ABO and Rh
→ Most people's understanding of blood types is limited to four types: A, B, AB, and O, with at most one additional "panda blood" (RhD negative). However, reality is far more complex than textbooks. As of 2025, the International Blood Transfusion Association has confirmed48 independent blood type systems, including371 antigensThat's right, your red blood cells may be attending an antigen party without your knowledge.
→ Among them, the Kidd blood type systemJk(a-b -) is referred to as "diamond blood" by Chinese media because its occurrence rate in the Chinese population is only 0.002% -0.02%, which is a hundred times rarer than "panda blood" (0.2% -0.5%). Even more exaggerated isRhnullBlood type - on red blood cellsComplete QUAN missing all Rh antigens(More than 50 types!),QUAN ballLess than 50 cases were recorded, earning it the title of 'golden blood' by French scientists. Ironically, this kind of "gold" is more like a curse to its owners: they can hardly accept any routine blood transfusions, as even the most common type O blood can trigger fatal hemolytic reactions.
Detection technology: from antibody dependence to gene editing
→ In the past, identifying these rare blood types was like searching for a needle in a haystack. Traditional methods rely on specific antibodies for serological reactions, which are not only expensive, but also many antibodies themselves are extremely scarce - after all, who would mass produce reagents that are only used for a few dozen people?
→ But in recent years, the rise of molecular detection technology has changed the rules of the game.Some forward-looking unitsAlready turnedHigh-throughput genotypingandNext Generation Sequencing (NGS)Significantly reducing dependence on antibodies and achieving routine rare blood type screening for voluntary blood donors. By 2025, only 9 cases of "diamond blood" will be screened out, and there are already over 300 in inventoryExamples of various typesRare blood types, some of which have been used for clinical treatment.
→ Scientists are trying it outCRISPR gene editing technologyManufacturing rare blood type red blood cells in the laboratory. For example, the Resilience project in the UK is dedicated to cultivating universal or specific rare blood type red blood cells from stem cells, with the goal of making "golden blood" no longer dependent on those 50 live donors. Although the current production is limited and the cost is astonishing, it at least proves that in the future, we may be able to "order" rare blood types like ordering takeout.
Regional differences: Your blood type may be common in Yunnan, but rare in Shanghai
→ It is interesting that the distribution of rare blood types is extremely uneven. For example, the detection rate of Mumbai like blood type ("dinosaur blood") in Shanghai is about 1/40000, but in some areas of Fujian it can reach as high as 1/8000; P-type blood is a miracle of one in a million in Shanghai and among the Lahu ethnic group in YunnanHowever, 2% of the people in the village carry it. This reminds us:Rarity is relative, location is the keyThe construction of a rare blood type database in the future will greatly improve the efficiency of cross regional allocation.
Future outlook: From passive screening to active prevention
→ Despite the exciting technological advancements, reality remains fragile. Currently, the vast majority of rare blood types are inAfter the patient experiences transfusion reactions or hemolytic disease of the newbornJust discovered. This means that many carriers had no idea they were "different" before the crisis broke out.
→ Therefore, future directions should include:
→ Expand routine genetic screening for voluntary blood donorsEspecially in high-risk areas;
→ Establish a rare blood type registration and sharing platformRealize the goal of 'one person entering the database, benefiting the whole country';
→ Promote autologous blood storage plan——Pre storing one's own blood before surgery is a safe choice for individuals with known rare blood types;
→ Accelerate the development of artificial bloodMake the laboratory a 'blood bank'.
Conclusion: Your blood may be someone else's' life key '
just asour countryThe expert from the blood center said, "The 'life gift' you give may contain the life key of a rare blood type patient." In this era where even coffee can be customized, blood is still nature's most precious giftTreasure GUIThe gift. Whether you are a common O-type or the legendary 'golden blood', regularly donating blood is not only a good deed, but also a way to insure human genetic diversity.
After all, in this world, there are always people whose lives are truly tied to your blood - even if you don't know how special your blood type is.
Voice of VirtueProvide various conventional and rare blood type reagents, including ABO, Rh, KELL, MNSs, P1、 Duffy, Kidd, Lewis, etc,We can provide IgM monoclonal antibody and IgG polyclonal antibody reagents European professional laboratory quality, reliable and stable experimental results, and multiple packaging specifications to choose from
Product Name |
Product Usage/Features |
Red blood cell test kit for ABO blood typing in humans |
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Anti-B blood typing reagent |
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Anti D【IgM+IgG blood typing reagent |
hybrid |
Product Name |
Product Usage/Features |
|
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Anti-A |
Mouse monoclonal antibodyIgM [BIRMA-1] |
Anti-B |
Mouse monoclonal antibodyIgM [LB-2] |
Anti A, B |
Mouse monoclonal antibodyIgM [ES-4/ES-15] |
Anti-D [IgG and IgM] |
Human monoclonal IgM/IgG [MS-26 or RUM-1] |
抗D IgM |
Human monoclonal antibody [RUM-1] |
Anti-D IgG |
Mouse monoclonal antibody[EBV transformed human B lymphocyte line] |
Anti A, B, D [IgG and IgM] |
monoclonal |
Anti A, B, AB, D [IgG and IgM] |
monoclonal |
|
|
Coombs green anti human globulin |
Rabbit anti human IgG BIRC [AntiC3d], multispecific |
Coombs transparent anti human globulin |
Rabbit anti human IgG BRIC-8 [AntiC3d], multispecific |
Anti human globulin IgG [Coombs] transparent |
Monospecific |
22% bovine serum albumin |
|
30% bovine serum albumin |
|
|
|
Anti A1 |
Exogenous lectin |
Anti A1 |
Exogenous lectin |
Anti - N |
Person [Virginia]graminae] |
|
|
Anti - C |
Human monoclonal IgM [MS-24] |
Anti - C |
Human monoclonal IgM [MS-24] |
Anti-c |
Human monoclonal IgM [MS-33] |
Anti-c |
Human monoclonal IgM [MS-33] |
Anti CDE |
Human monoclonal IgM/IgG [MS-24/MS-201/MS-26/MS-80] |
Anti CDE |
Human monoclonal IgM/IgG [MS-24/MS-201/MS-26/MS-80] |
Anti - E |
Human monoclonal IgM [MS-80/MS-258] |
Anti - E |
Human monoclonal IgM [MS-80/MS-258] |
Anti - e |
Human monoclonal IgM [MS-16/MS-21/MS-63] |
Anti - e |
Human monoclonal IgM [MS-16/MS-21/MS-63] |
Anti-K [Kell] |
Human monoclonal IgM [MS-56] |
Anti-K [Kell] |
Human monoclonal IgM [MS-56] |
Resistance -Cw |
Monoclonal [MS-110] |
Rh Control |
|
|
|
Anti P1 |
Mouse monoclonal antibodyIgM [650] |
Anti - S |
Human monoclonal antibodyIgG [P3S13JS123] |
Anti - s |
Human monoclonal antibodyIgG [P3YAN3] |
抗‐Fya |
Monoclonal IgG [DG-FYA-02] |
Anti Fyb |
Human Source [SpA264LBg1] |
抗‐ k 【Cellano】 |
Human monoclonal antibodyIgG [AEK4] |
Resistance to Kpa |
Human source [KPA] |
抗‐Kpb |
Human source [KPB] |
Anti Jka |
Human monoclonal IgM [MS-15] |
Anti Jkb |
Human monoclonal IgM [MS-8] |
Anti Lua |
Human Source [LU1] |
Anti Lub |
monoclonal |
Anti Dia |
polyclonal |
Anti Lea |
Human monoclonal antibodyIgM [P3N20V3] |
Anti Leb |
Mouse monoclonal antibodyIgM [LEB2] |
Anti - M |
Human monoclonal antibody[LM1] |
|
|
Low ionic strength solution |
Working Strength |
Low ion strength solution+addition |
With BSA Additive |
|
|
Paper enzyme |
|
bromate |
Bromelinbromelain |
3 Cell Screen inAlsevers |
NHSBT |
Panel 1, 10 Cell Screen |
NHSBT |
ModifiedAlsevers |
Red blood cell preservation solution [Achille's solution] |
Cryoprotectant Reagent |
Low temperature protective reagent [CPP] |
Red Cell Support Solution |
Red blood cell support solution [RCSS] |
Frozen Cell Recovery Solution |
Frozen Cell Recovery Solution [FCRS] |
Anti H |
Exogenous lectin |
Anti-H |
Exogenous lectin |
Anti-H |
Exogenous lectin |
Product Name |
Product Usage/Features |
|
|
anti-human globulin |
IgG/C3D multispecific antibody, rabbit anti [green] |
| |
Anti A |
A-11H5 |
Anti B |
B-6F9 |
Anti AB |
IgM[克隆株A-5E10,B-2D7] |
Anti A1 |
Exogenous lectin |
Anti A1 |
Exogenous lectin |
Anti H [A2] |
Monoclonal 1093 4C11 |
Anti H [A2] |
Monoclonal 1093 4C11 |
|
|
Anti D |
IgG, Polyclonal, non WAN whole antibody, used for weak D detection |
Anti D |
IgM[克隆株MS201] |
Anti D |
IgM [clone RUM-1] |
抗 D[M+G] |
D-monoclonal blend-TH28/MS-26 |
Anti C |
IgM clone [MS24] or [MS273] |
Anti C |
IgM clone [MS33] or [MS35] |
resistCw |
Polyclonal, non WAN full antibody |
resistCw |
Polyclonal, non WAN full antibody |
resistCw |
IgM克隆株 [MS110] |
Anti E |
IgM [clone MS80/258] or [MS12/260] |
Anti E |
IgM [clone MS16/21/63] or [MS62/69] |
| |
抗 k[cellano] |
IgG, Polyclonal, used for anti human ball testing |
抗 k[cellano] |
IgG, Polyclonal, used for anti human ball testing |
Anti Kell |
IgG, Polyclonal, used for anti human ball testingcoombsreactive |
Anti Kell |
IgG, Polyclonal, used for anti human ball testingcoombsreactive |
Anti Kell |
IgM[克隆株AEK4] |
Anti Kell |
IgM[克隆株AEK4] |
Anti Kell |
IgM[克隆株MS56] |
Anti Kell |
IgM[克隆株MS56] |
Anti Kpa |
IgG, Polyclonal, used for anti human ball testing |
抗 Kpb |
IgG, Polyclonal, used for anti human ball testing |
| |
Anti M |
IgG[克隆株11H2] |
Anti M |
IgG[克隆株11H2] |
Anti N |
IgM[克隆株1422C7] |
Anti N |
IgM[克隆株1422C7] |
Anti S |
IgG, Polyclonal, used for anti human ball testing |
Anti S |
IgG, Polyclonal, used for anti human ball testing |
Anti S |
IgM[克隆株MS94] |
Anti S |
IgM[克隆株MS94] |
Anti s |
IgG, Polyclonal, used for anti human ball testing |
Anti s |
IgG, Polyclonal, used for anti human ball testing |
Anti s |
IgM[克隆株P3BER] |
Anti s |
IgM[克隆株P3BER] |
Anti P1 |
IgM[克隆株650] |
Anti P1 |
IgM[克隆株650] |
| |
抗 Fya |
IgG, Polyclonal, used for anti human ball testing |
抗 Fya |
IgG, Polyclonal, used for anti human ball testing |
Anti Fyb |
IgG, Polyclonal, used for anti human ball testing |
Anti Fyb |
IgG, Polyclonal, used for anti human ball testing |
Anti Jka |
IgG, Polyclonal, used for anti human ball testing |
Anti Jka |
IgG, Polyclonal, used for anti human ball testing |
Anti Jka |
IgM[克隆株MS15] |
Anti Jka |
IgM[克隆株MS15] |
Anti Jkb |
IgM[克隆株MS8 ] |
Anti Jkb |
IgM[克隆株MS8 ] |
Anti LEA |
IgM[克隆株lEA2] |
Anti LEA |
IgM[克隆株lEA2] |
resistleb |
IgM[克隆株lEB2] |
resistleb |
IgM[克隆株lEB2] |
| |
Anti Dia |
IgG, Polyclonal, used for anti human ball testing |
Anti Lua |
IgG, Polyclonal, used for anti human ball testing |
Anti Lub |
IgG, Polyclonal, used for anti human ball testing |
Anti Wra |
IgG, Polyclonal, used for anti human ball testing |
Anti Xga |
IgG, Polyclonal, used for anti human ball testing |
| |
Monoclonal antibody quality control reagent |
KontRea-mono-10 |
| |
Pineapple protease quality control reagent |
|
Bromelain solution |
|
22% bovine serum albumin |
|
30% bovine serum albumin |
|
lissreagent |
|
improvelissreagent |
|
Alzef solution |
Cell stabilizer, diluent |
| |
Cartwright[a] |
Cartwright blood type system |
Chido[a] [C4B*3] |
Chido/Rodgers blood type system |
Rodgers[a] [C4A*3] |
Chido/Rodgers blood type system |
CROM/DAF [Cr[a]/Dr[a]] |
Cromer blood type system |
Dombrock [ edit ] |
Dombrock blood type system |
Dombrock[b] |
Dombrock blood type system |
Duffy[a] |
Duffy blood type system |
Duffy[b] |
Duffy blood type system |
Indian[b] |
Indian blood type system |
JMH |
John Milton Hagen blood type system |
Cellano-Kpb-I am |
Kell blood type system |
Kell-Kpb-I am |
Kell blood type system |
Knops[a] |
Knops blood type system |
landsteiner-Wiener [a] |
landsteiner-Wiener blood type system |
lutheran[a] |
Lutheran blood type system |
lutheran[b] |
Lutheran blood type system |
Scianna1 |
Scianna blood type system |
Xg[a] |
XG blood type system |
| |
C4B*3 |
Recombinant Chido blood type protein |
Kn[a),McC[a),SI[a),SI3+ |
Recombinant Knops blood type proteinKn[a) Antigen |
Cr[a+),Tc[a],Dra+,Esa+,IFC+,WES[b),UMC+,GUTI+ |
Recombinant Cromer blood group protein Dr [a) antigen |
Do[a),Hy+,Jo[a+) |
Recombinant Dombrock blood group protein with Do [a) antigen |
Do[b),Hy+,Jo[a+) |
Recombinant Dombrock blood group protein with Do [b) antigen |
Fy[a) |
Recombinant Duffy blood type proteinFy[a) Antigen |
Fy[b) |
Recombinant Duffy blood type proteinFy[b) Antigen |
Js[a),K12+,UI[a-),K19+,Tou+,K23+,K13+,K22+,K11,Kp[b),Raz+,Vlan+,K,K14,K18+ |
Recombinant Kell blood type proteinKp[b) and K antigen |
In[b) |
Recombinant In [b) antigen of Indian blood group protein |
JMH |
Recombinant JMH blood type protein |
Js[a),K12+,UI[a-),K19+,Tou+,K23+,K13+,K22+,K11,Kp[b),Raz+,Vlan+,k,K14,K18+ |
Recombinant Kell blood type proteinKp[b) and k antigen |
Lu[a),Lu4+,Lu5+,Lu6,Lu8,Lu12+,Lu13+,Lu16+,Lu17+,Lu20+,Lu21+ |
Recombinant Lutheran blood group protein with Lu [a) antigen |
Lu[b),Lu4+,Lu5+,Lu6,Lu8,Lu12+,Lu13+,Lu16+,Lu17+,Lu20+,Lu21+ |
Recombinant Lutheran blood group protein with Lu [b) antigen |
LW[a) |
LW [a) antigen of recombinant L and steam Wiener blood group proteins |
C4A*3 |
Recombinant Rogers blood type protein |
Sc1,Rd- |
Recombinant Scianna blood type proteinSc1antigen |
Xg[a) |
Recombinant Xg [a) antigen of Xg blood group protein |
Yt[a) |
Recombinant Cartwright blood type proteinYt[a) Antigen |
| |
Anti-CD38 antibody neutralizing agent |
Compound inhibits the agglutination of anti-CD38 in IAT |
Virtue Voice Professionalprofessional service
u antibody screening|Identification and red blood cell reagents, Conventional blood type reagents
u Covering various strains, monoclonal antibodies, and multi antibody rare blood type reagents
u resistCD38 Antibody Neutralizer - DaraEx and DaraEx Plus Reagents
u RBC Ready SSP-PCR method for genotyping red blood cell blood types
u RBC-FluoGene® – Fluorescent PCR reagent
u RBC-NGS type ® Next generation blood typing system sequencing and high-resolution typing
High quality raw materials ensure high-quality products!
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