USP L43 pentafluorophenyl column PFP

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USP L43 pentafluorophenyl column PFP

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USP L43 pentafluorophenyl column PFP

According to the requirements of the United States Pharmacopeia USP L43 for chromatographic columns:Silicone microsphere bonded pentafluorophenyl stationary phase，Vertex PFP pentafluorophenyl columnThere are 5 fluorine atoms on the benzene ring, which are retained based on dipole dipole interactions. Compared with similar products, Vertex PFP can achieve good separation effect in a short time under the same chromatographic conditions, achieving rapid separation.

Replacing the hydrogen atoms on the carbon chain of the reverse phase stationary phase with fluorine atoms, the fluorine-containing stationary phase not only has high selectivity for fluorine-containing and halogen containing compounds, but can also be used as a common reverse phase stationary phase for separating compounds without fluorine or halogen, providing different selectivity from the C-H alkyl stationary phase. In recent years, it has been widely used in biopharmaceuticals, natural products, and environmental analysis.

Fluorinated fixed phase has stronger ion exchange and polarity separation characteristics compared to alkyl fixed phase, and has good selectivity for some polar metabolites;

In addition, fluorinated stationary phases have strong geometric size and stereoselectivity, and can separate substances with similar structures that are difficult to separate with alkyl stationary phases.

♦ It has unique selectivity for drugs containing benzene rings, nitrobenzene, and conjugated systems.
♦ Strong retention of highly polar samples such as halogenated compounds
♦ Has high selectivity for positional isomers, especially suitable for the separation of paclitaxel compounds

♦ Has good retention for alkaline analytes. It is a good stationary phase for analyzing nucleosides, nucleotides, purines, pyrimidines, halogenated compounds, beta blockers, and tricyclic antidepressants.

The Vertex series mainly has two types of fluorinated stationary phases: Vertex PFP (pentafluorophenyl column) and Vertex F-C8 (perfluoroC8 column).

Vertex PFP pentafluorophenyl column

Used for the separation of fluorinated compounds and natural products of paclitaxel, PFP is different from other fluorinated alkyl stationary phases due to the presence of benzene rings

Compounds also have high selectivity

Vertex F-C8

Vertex Fluorinated Column Specification:

specifications	Particle size
2.1×150mm	3μm
4.6×150mm
4.6×250mm
4.6×300mm
2.1×150mm	5μm
4.6×150mm
4.6×250mm
4.6×300mm

referenceswww.htcee.com

United States Pharmacopeia USP L43（Silicone microsphere bonded pentafluorophenyl stationary phase）Vertex PFP column, Vertex PFP pentafluorophenyl column, USP L43PFP column