Thermo Fisher liquid chromatography-mass spectrometry Quantum Access MAX

Thermo Fisher liquid chromatography-mass spectrometry instrumentQuantum Access MAX

The Thermo Fisher Quantum Access MAX triple quadrupole mass spectrometer is capable of performing highly selective reaction detection capability (H-SRM) analysis, utilizing Thermo Fisher's enhanced quantitative data association secondary scanning (QED-MS/MS) system for both quantitative and qualitative analysis. It significantly improves the sensitivity and accuracy of testing actual samples, greatly reducing the pressure on customers in sample pretreatment work. Used for the quantification and confirmation of trace components in complex matrices, applicable to the environment, food safety, and pharmacokinetics.

Key Features:

Enhanced Quantitative Data Correlation Secondary Scanning (QED-MS/MS) System: Simultaneously perform quantitative and qualitative analysis. The specificity provided by High Selective Reaction Monitoring (H-SRM) is complementary to QED-MS/MS, providing you with outstanding low concentration quantitative performance, accompanied by rapid and highly specific full secondary spectral scanning for confirmation.

Multi component screening: The ability of timed SRMs and trigger data dependent full scan mass spectrometry/mass spectrometry brings multidimensional specialization to multi-component screening experiments. The use of H-SRM induced sub ion scanning minimizes the possibility of false positive results, especially in complex sample analysis. The outstanding specialization increases confidence in the analysis results.

Fast polarity conversion: Fast power conversion enables fast conversion of positive/negative ion modes, allowing the instrument to capture high-quality data in both positive and negative ion modes simultaneously. This is of great value for sample analysis that contains compounds of multiple categories and requires analysis in two polarity modes.

Performance indicators of Quantum Access MAX mass spectrometer

M/z range: 10-3000 amu

Zei high resolution: ≥ 10M

a) Eliminating false positive detections with molecular weight differences<0.7 amu

b) Improve the measured sensitivity of trace drug detection in complex backgrounds

c) Eliminating endogenous differences between samples, increasing the reliability and portability of the method

d) Clear resolution of multi charge peaks (>10 charges) of biomolecules, enabling the determination of higher quality biomolecules

Quality stability:+/-0.050 amu/24 hours

Scanning speed: Full range scanning 5000u/s

H-SRM dwell time:<2ms

Conversion time of positive and negative polarity spectra:<25ms

3000 timed SRMs (T-SRMs)

Sensitivity (SRM selects peak to peak ratio sensitivity for reaction monitoring):

a）ESI： 1pg ， Peak to peak signal-to-noise ratio (S/N) better than 200:1

b）APCI：1pg ， Peak to peak signal-to-noise ratio (S/N) better than 200:1

H-ESI II atmospheric pressure ionization source

a) Ion spray needle with x, y, z three-way gear adjustment can use different positions to optimize spray according to sample conditions

b) Equipped with blow off gas technology, non-volatile buffer solution can be used to reduce chemical background noise

c) All metal transmission tube, metal block heated from 0 to 400 ℃ to prevent ion condensation from blocking the transmission tube during gasification

d) Equipped with a vacuum locking device, the ion transport tube can be cleaned and maintained without stopping the machine

e) Nitrogen consumption during sample preparation: 0.5-4 liters/minute, no nitrogen consumption in standby mode, one regular nitrogen cylinder can support continuous sample preparation for more than 3 days

f) ESI source nozzle performance: flow rate of 1uL~1mL/min, 100% H2O without diversion

g) Performance of APCI source nozzle: flow rate of 50 uL~2mL/min, 100% H2O without diversion

Quality analyzer: Hyperbolic series quadrupole

a) Q1 and Q3 use hyperbolic quadrupole rods, which are 100% consistent with the theoretical quadrupole field, ensuring high resolution

b) RF frequency of 1.1M ensures high resolution

c) 90 degree bent Q2 quadrupole to reduce neutral particle noise

d) Quickly reset the voltage of Q2 to zero within 5 milliseconds, without any memory effect when changing the scanning speed and sample concentration

vacuum system

a) Three channel high vacuum oil-free molecular turbopump system, air-cooled, no need for water cooling, forming a differential pumping system between the source and analysis areas.

b) The pumping speed of Q2 area is 400 L/sec, ensuring high sensitivity of zei and reducing the pressure of the ion source area pump

c) A low vacuum system composed of a single high pumping speed solvent pre stage mechanical pump.

detection system

a) The acceleration conversion electrode after ± 15kV has improved the detection sensitivity and dynamic range.

b) Vertical 90 degree electron multiplier, computer-controlled with variable voltage ranging from 0 to ± 3kV.

Integrated uniform peristaltic injection pump injection system and automatic switching valve (desalination valve) on the panel

Data processing method:

a) Scanning functions: Full range scanning, selective ion scanning, selective reaction tandem mass spectrometry scanning, sub ion scanning, parent ion scanning, neutral loss scanning, multi reaction monitoring scanning, mixed scanning, fast switching of positive/negative ions scanning, automatic MS and MS/MS switching scanning functions

b) High selectivity reaction monitoring (H-SRM), Q1 can be adjusted to 0.1 FWHM

c）QED MS/MS&trade; Function: Simultaneous qualitative and quantitative analysis in one experiment: Automatically collect a full scan MS/MS spectrum after each quantitative MRM spectrum

d）RER&trade; Function: Reverse collision energy linear ladder: adopts gradient linear energy to automatically obtain LC/MS/MS spectra

e) LC/MS/MS spectrum library for agriculture, veterinary medicine, and dyes:>700 images

f) LC Quan 2.5 Multi Component Simultaneous Automatic Optimization Software

g) Real time related data processing function: automatically identify the mass spectrum of chromatographic effluent, and according to user requirements, automatically perform MS/MS on a certain ion to obtain its structural information

h) Isotope real-time related data processing function: When user-defined isotope ratios are detected, the instrument automatically performs MS/MS tandem mass spectrometry analysis

i) Dynamic exclusion function: When analyzing complex co effluent, after collecting MS/MS information of high-intensity ions, they are listed on a temporary exclusion ion table, while continuing to provide structural information of other co effluent ions with relatively weak signals

Data system:

a) Mainstream computer workstations, high-resolution laser printers

b) Microsoft Windows XP operating system Microsoft Office XP

c) Data processing and instrument control software, quantitative software packages, browsers for quantitative and qualitative analysis

Working environment conditions

Working voltage: 230V ± 10%

Temperature: 15-270C

Humidity: 40-80%

Thermo Fisher liquid chromatography-mass spectrometry instrumentQuantum Access MAX

Quality assurance service

The whole machine is covered by a one-year warranty (calculated from the date of installation and commissioning).

During the warranty period, we provide free services to customers. Outside the warranty period, we provide customers with paid testing and maintenance services according to the company's unified charging standards.

Service hours: Monday to Friday 9:00-17:00.

Customer feedback processing: Respond to customer feedback and suggestions within 1 working day.

Customer complaint handling: Resolve or provide a clear solution within 1 working day.

Warranty certificate:

If the product malfunctions within the warranty period specified in the three guarantees, the user must handle the warranty business with the purchase invoice and product warranty certificate, and the product number must be consistent with the product number on the warranty certificate. If there is no invoice, the warranty period will be calculated based on the product number.

Situations that do not fall under the obligation of free warranty:

1) Cannot prove the valid warranty period of the product.

2) The natural consumption, wear and aging of consumable materials.

3) Damage caused by lightning strikes or other electrical system reasons.

4) Damage caused by force majeure factors such as accidents, disasters, wars, etc.

5) Self modification, repair, or disassembly, modification, or repair by a third party who is not our company.

6) Damage caused by failure to use, maintain, and store the product in accordance with the instructions.