Sievers Eclipse bacterial endotoxin detector

Breakthrough technology enables automation and compliance

innovativeSievers Eclipse bacterial endotoxin detectorIt can shorten the preparation time for laboratory tests by 85%, reduce the usage of Li Amebocyte Lysate (LAL) by 90%, and meet all the requirements of the standardized pharmacopoeia: USP<85>, EP 2.6.14, and JP 4.01. Through pioneering technology,Sievers Eclipse bacterial endotoxin detectorSignificantly reduced the number of pipetting steps, minimized differences among operators, and simplified laboratory preparation. The Eclipse platform utilizes microfluidic processing and embedded endotoxin for automated dynamic colorimetric assay. The detection capacity of 21 samples on each board does not require complex robot technology, nor does it require the time and technical requirements required for traditional laboratory testing.

Compliant, consistent, and clear bacterial endotoxin testing

Sievers Eclipse bacterial endotoxin detectorAutomated and high-precision BET analysis can be achieved without sacrificing compliance, biochemical reactions, or laboratory footprint. Only 30 pipetting steps are required to use embedded endotoxin standards and positive product control (PPC). Sievers Eclipse microplates can achieve automated operation without the tedious operation or cost of robots.

Characteristics and advantages of Eclipse platform laboratory

• Only 9 minutes to achieve * compliant 21 sample assay settings

• Reduce the usage of horseshoe crab reagent by 90%

• Meets all requirements of the pharmacopoeia: USP

  <85>, EP 2.6.14 and JP 4.01

• Built in endotoxin for standard curve and positive product control PPC

• Provide zoning of standard curves, samples, and positive product control PPC

• Sensitivity as low as 0.005 EU/mL

• Enterprise software complies with 21 CFR Part 11 and data reliability guidelines

• Reduce the need for extensive operator training

• Reduce the risk of repetitive stress injuries

• Increase daily sample completion volume

• Use commercially available and FDA approved horseshoe crab reagent LAL

• Use a cultivation absorbance analyzer to control the reaction temperature at 37+/-1 ℃

Composition of Eclipse Platform

• Analyzer:Absorbance analyzer, stable cultivation control at 37 ° C, centrifugation technology, and secure data transmission.

• Microplate:Liquid processing equipment, this technology achieves automation through innovative microfluidic technology with embedded endotoxin standards and positive product control (PPC).

• Software:Highly customizable enterprise solutions that comply with 21CFR Part 11 and ALCOA+data integrity.

Eclipse microplate is used in conjunction with Eclipse analyzer and software to measure and evenly distribute reagent water, sample, and horseshoe crab reagent LAL in a 104 optical cell using centrifugal force and pneumatic chamber. The optical cell includes partitions for standard curves, samples, and positive product control PPC. Control the reaction at 37+/-1 ° C and obtain a high-definition view of each cell by obtaining a reading of 405 nm every five seconds.

Eclipse specifications