PurePep automatic peptide synthesizer; Sonata®+

PurePep®Sonata®+

Reliable amplification of production and improvement of productivity

new generationPurePep®Sonata®+Instrument in our single channel pilot scale peptide synthesizerSonata®XTBuilding on the foundation, continuing its quality and excellent functionality.PurePep Sonata+Has inter batch reliability in terms of pre production scale and productivity level, meetingCRO/CMOAnd pharmaceutical companies need it.21CFR Part 11Compliant and intuitive software and hardware upgrades enablePurePep Sonata+Easy to operate. Inheriting proprietaryPurePep®PathwayValve block system, in coordinationSingle-ShotLiquid delivery technology eliminates the risk of cross contamination of reagents and ensures peptide purity. Variable mixing mode improves productivity.

Real time traffic monitoring technology

Accurate liquid delivery, low calibration requirements

Real time traffic monitoring technology isPurePep Sonata+The technology ensures the accuracy and precision of liquid delivery by continuously monitoring the flow rate. This technology is based on the principle of sonar and measures flow velocity by sending sonar signals in both directions. Only one calibration is required for liquids of different viscosities, reducing user calibration to save time. This technology maintains accuracy even when the flow rate changes, measuring errors for various liquids<5%.

Intuitive software

The graphical software platform simplifies the setup of peptide synthesis methods and accelerates the establishment of peptide synthesis methods. The preset standard experimental plan can be used as a self-designed template to improve efficiency and flexibility; And it can easily import sequences to avoid errors. It allows programming new synthesis tasks while the current synthesis is running, thereby improving production efficiency. This software complies with21 CFR part 11Requirement: Ensure that the instrument is suitable for highly regulated environmentscGMPLaboratory environment.

Single Shot pre activation

By using a specially designed three port flow path module, alternating flow paths can be achieved to optimize the solvent delivery to the amino acid bottle and achieveSingle-ShotPre activation. Thanks to efficient blocking valves and pipeline cleaning, the purity of the product has been improved.

PurePep Pathwaytechnology

Proprietary chemical inert valve block systemPurePep PathwayandSingle-ShotThe pre activation function jointly eliminates the risk of cross contamination of reagents and improves the purity of synthesized short peptide and long peptide crude products.

Multiple mixing modes

PurePep Sonata+A chemically inert and optimized flow channel that can achieve high solution transfer rates for any solvent（>400 mL/min）. All reactions are carried out in an inert environment to minimize side reactions. Multiple mixing modes include nitrogen bubbling, variable speed oscillation, and recirculation, which can be used alone or in combination to improve reaction efficiency.

Enhanced pumps and other hardware

A fast and flexible main solvent pump with chemical resistance and extremely low maintenance requirements. PTFE lined circulating pump with high solvent tolerance and easy maintenance. Easy connection to external solvent and waste liquid systems.GL45The configuration of amino acid bottles provides great flexibility. adoptSingle-ShotPre activation technology can achieve higher purity without the risk of reagent cross contamination.

Solvent and reagent positions

Seven solvent ports and twenty reagent ports allow for easy customization of any synthesis scheme. Real time flow technology can accurately transport all solvents and reagents. To reduce disposal costs, two waste liquid ports allow for separation of waste liquid streams. A collection port can be configured to collect cutting products or recycle valuable reagents, thereby achieving multifunctionality.

Installation and Operation Qualification (IQ/OQ)

Installation confirmation（IQ）Confirm with operation（OQ）Support services, with certified engineers ensuring strict compliance of instruments from delivery, installation to operationGPTStandardize and generate complete files for youcGMPProvide solid support for operations under regulatory environments.