Piuma biomechanical indentation of biological tissue

NegotiableUpdate on 06/26

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Overview

Piuma is a revolutionary product that is simple and easy to use. Piuma's histopathological and mechanical analysis of biological tissues brings hope for micro - and nano level research on soft matter and biomaterial tissues. By relying on its self-developed new optical technology and outstanding microfabrication processes, Piuma Biological Tissue Mechanics Indentation can measure the softest Young's modulus samples, ranging from 5Pa to 5GPa! Piuma is also very suitable for testing samples in liquids. Its operation is very simple and easy to learn. Simply insert the probe into the instrument, calibrate it briefly, and start the indentation experiment immediately.

Product Details

Optics10 was founded in 2011 and is a spin off organization of the Free University of Amsterdam (VU). Since then, the revenue and employees of this startup have continued to grow, becoming one of the fastest-growing companies in the Netherlands and having international influence. Optics10 Life provides a new type of nanoindentation instrument with features that are convenient to use, versatile, and durable compared to traditional similar products. It is mainly used to measure the mechanical properties of complex and irregular biological materials, such as single cells, tissues, hydrogels and coatings.

Piuma Nanoindenter

A new method for testing the mechanical properties of biological tissues and soft matter materials

PiumaIt is a desk top instrument with function *, which can explore the micromechanical properties of hydrogels, physiological tissues and bioengineering materials. The scale of representation ranges from macroscopic to cellular. Specially designed for analyzing and testing soft materials, measuring the mechanical properties of complex and irregular materials under physiological conditions. Hangzhou Xuanyuan Technology Co., Ltd

main advantages

●Built in camera lens, convenient for real-time observation of the sample stage

●Real time analysis and calculationmeasurement resultsThe raw data will be stored in text files for easy import into Dataviewer software for complex processing at any time

●The probe is pre calibrated and plug and play. Ensure rapid measurement for time sensitive samples

●Fiber optic interference MEMS technology can measure even the softest materials in a non-destructive manner and ensure resolution. At the same time, the probe can be reusedPiuma biomechanical indentation of biological tissuePiuma biomechanical indentation of biological tissue

Technical specifications

Modulus testing range	5 Pa - 1 GPa
Probe cantilever stiffness	0.025 - 200 N/m
Probe size (radius)	3 - 250 μm
Maximum indentation depth	100 μm
Maximum sensor capacity	200
test environment	air, liquid (buffer/medium)
Rough adjustment of travel	X*Y：12×12 mmZ：12 mm
loading mode	Displacement / Load* / Indentation*
Test Type	Quasi static (single point, matrix) Creep, stress relaxation DMADynamic scanning(E', E'', tanδ)
Dynamic scanning frequency*	0.1 - 10 Hz
Built in fitting model	Young's Modulus (Hertz / Oliver-Pharr / JKR)
*Optional upgrade configuration

Fiber On Top probe

The new fiber optic interferometric cantilever beam probe uses an interferometer to monitor the deformation of the cantilever beam.

Compared to atomic force microscopy or traditional nanoindentation instruments

The innovative fiber optic probe compensates for the problem of traditional nanoindentation instruments being unable to test soft materials, and also solves the common defects of AFM in mechanical testing, such as large fluctuations, difficult operation, and strict sample preparation.

●Low background noise: Laser interferometer has stronger anti-interference ability than AFM reflection path

●Simpler sample preparation: higher tolerance for sample roughness than AFM

●More accurate stiffness selection: The parallel cantilever beam structure is conducive to accurately distinguishing the proportional relationship between indentation depth and piezoelectric ceramic displacement, facilitating the selection of appropriate stiffness probes to ensure the stability of elastic deformation relationships, and thus obtaining data with higher repeatability and better accuracy

Built in analysis software

●With the help of functional and easy-to-use software, users can freely operate itControl the indentation program (load, displacement, etc.). The process of automatically processing curves enables rapid analysis of data and results

●Export the original parameters in complete txt format for the convenience of subsequent complex processing needs

●Using the Hertz contact model to calculate the elastic modulus from the loading section is more suitable for the characteristics of biological tissues and soft material materials compared to the commonly used Oliver&Harr method

Video Introduction

Recent literature

Year	Journal	Title:
2022	Advanced Functional Materials	Engineering Vascular Self-Assembly by Controlled 3D-Printed Cell Placement
2022	Biomaterials	Hydrogels derived from decellularized liver tissue support the growth and differentiation of cholangiocyte organoids
2021	Biofabrication	3D bioprinting of tissue units with mesenchymal stem cells, retaining their proliferative and differentiating potential, in polyphosphate-containing bio-ink
2021	nature communications	Janus 3D printed dynamic scaffolds for nanovibration-driven bone regeneration
2020	Environmental Science & Technology	Effect of Nonphosphorus Corrosion Inhibitors on Biofilm Pore Structure and Mechanical Properties
2020	Acta Biomaterialia	A multilayer micromechanical elastic modulus measuring method in ex vivo human aneurysmal abdominal aortas