Pharmaceutical industry

Pharmaceutical industry

The production of solid dosage typically begins with shaping the resulting particles into particles ranging in size from 0.1 to 10 μ m. The measurement of particle size and shape is often important as it can provide extremely useful information for the manufacturing process. It has been proven that particle size also affects dissolution rate, content uniformity, and deposition rate.

**The second stage of the manufacturing process usually involves bonding particles together to form a large granule of medicine. Generally, the size of the drug particles made is about a few millimeters, showing better flow characteristics. Because the roughness of the drug particle surface is closely related to the manufacturing process, its measurement is important. The final stage of the tablet manufacturing process usually involves coating the tablet, which has multiple uses including isolating the tablet from air and preventing diffusion. In the manufacturing process of tablets, there are certain requirements for the surface structure of the tablet coating, as it is closely related to the diffusion rate of * *.

There are various requirements for the surface morphology and structure in the pharmaceutical production process. The most important thing is to ensure the surface roughness of the transmission pipeline and mold to minimize pollution. The pipelines used in pharmaceutical factories can be made of stainless steel or plastic, and the surface roughness Rq value of these pipelines ranges from 0.2 μ m to 2 μ m. Due to the consideration of a common type of rod-shaped cell such as Pseudomonas aeruginosa, which is approximately 0.3 to 0.8 μ m wide and 1 to 1.2 μ m long, strict requirements are placed on the surface roughness of the pipeline. If the surface roughness of the pipeline is not up to standard, this type of * * can occur, leading to contamination during the manufacturing process.