Nano optical tweezers

Surface particle analysis

Near field light scattering analysis of nanomaterials

main features

Measuring the surface particles of a single nanoparticle in its original ecological environment

background

The Importance of Surface Substances

According to the size of a particle, the importance of its surface material is increased. According to different nanometer sizes, most behaviors depend on their surface properties, but the ability to accurately measure the surface state of a particle has not yet been achieved. Whether a new batch of particles can still enter epithelial cells, concentrate at the tumor site, or accumulate proteins on the surface of a glass container after 2 weeks of aggregation depends on the surface properties of the particles. Nanoparticles and their applications in the medical field, the increasing use of electronic products, batteries, and household products have created an improved approach that meets more demands.

How to see the surface of optical tweezers

It is essential to comprehensively analyze and evaluate the surface properties of the dispersion and chemical colloid stability of nanoparticles. This type of optical tweezers improves the surface and force measurement methods for nanoparticles. The main principle is relatively simple and can systematically answer some questions; How much energy is needed to push the nanoparticles down to another level. Stable particles will repel each other (otherwise they will be fused). They also repel the same particles. These particles are difficult to form on the surface. Unstable particles, on the other hand, will be easier to push forward. The same concept applies to surface interactions of any particle: water-soluble, three-dimensional, electrostatic, etc

Waveguide measurement

This type of optical tweezers utilizes a unique waveguide based commercial technology for microfluidic optics. This novel technology utilizes lasers to drive particles and waveguides that interact with surfaces. The waveguide surface can be used for the design of professional coatings.

All of these indicate that surface interactions are very important

Main features

This optical tweezer can measure the surface properties of individual particles

Can study the interactions between various surfaces (charged, three-dimensional, etc.)

Manipulate in the original ecological environment of particles

Measurement accuracy over a large range

Can be operated in various granular materials

Controllable particles ranging from 20nm to 5 μ m

main features

Measuring the surface particles of a single nanoparticle in its original ecological environment

background

The Importance of Surface Substances

According to the size of a particle, the importance of its surface material is increased. According to different nanometer sizes, most behaviors depend on their surface properties, but the ability to accurately measure the surface state of a particle has not yet been achieved. Whether a new batch of particles can still enter epithelial cells, concentrate at the tumor site, or accumulate proteins on the surface of a glass container after 2 weeks of aggregation depends on the surface properties of the particles. Nanoparticles and their applications in the medical field, the increasing use of electronic products, batteries, and household products have created an improved approach that meets more demands.

How to see the surface of optical tweezers

It is essential to comprehensively analyze and evaluate the surface properties of the dispersion and chemical colloid stability of nanoparticles. This type of optical tweezers improves the surface and force measurement methods for nanoparticles. The main principle is relatively simple and can systematically answer some questions; How much energy is needed to push the nanoparticles down to another level. Stable particles will repel each other (otherwise they will be fused). They also repel the same particles. These particles are difficult to form on the surface. Unstable particles, on the other hand, will be easier to push forward. The same concept applies to surface interactions of any particle: water-soluble, three-dimensional, electrostatic, etc

Waveguide measurement

This type of optical tweezers utilizes a unique waveguide based commercial technology for microfluidic optics. This novel technology utilizes lasers to drive particles and waveguides that interact with surfaces. The waveguide surface can be used for the design of professional coatings.

All of these indicate that surface interactions are very important

Main features

This optical tweezer can measure the surface properties of individual particles

Can study the interactions between various surfaces (charged, three-dimensional, etc.)

Manipulate in the original ecological environment of particles

Measurement accuracy over a large range

Can be operated in various granular materials

Controllable particles ranging from 20nm to 5 μ m

Raman spectroscopy analysis

Main features:

Ultra high sensitivity microfluidic processing for submicron particle recognition

Raman spectra

Raman spectroscopy is a powerful analytical technique that uses laser materials to obtain chemical names. The energy transfer between a single wavelength of light and a chemical bond depends on the composite material. Spectrum is a unique material (glass, polystyrene, titanium dioxide, etc.) that can be regarded as a fingerprint.

Limitations of Raman Spectroscopy

Although Raman spectroscopy allows researchers to extract molecular fingerprints, Raman signals are usually very weak and difficult to obtain. Traditionally, lasers focus on bulk materials, powders, or accurately obtain more attractive solutions for separating and characterizing materials from the background. Until now, Raman systems can only be used for fixed (not in solution) and visible light (larger than a few micrometers) particles.

Application of Raman Spectroscopy in Optical Tweezers

Unlike other Raman microscopes that can only capture larger particles, this device can see the grooves of the optical tweezers and obtain real nanoparticles through Raman spectroscopy, instead of an external laser focusing on the substrate. It uses near-field light leakage to excite waveguide light and grooves on their source particles. This is a crucial breakthrough in improving performance. The strong light generated in the near-field results in less enhanced signal background compared to traditional lighting systems. In addition, as the particles are still in the analyzed state, the period for exposure and acquisition will be longer.