Mini tangential flow ultrafiltration system - membrane package and fixture

Tangential flow filtration technology is a commonly used membrane separation technique for sample concentration, dialysis, separation, and filtration. Typically, the cut-off molecular weight range is 1-1000 kd.

Ultrafiltration (UF) is a method for separating extremely small particles and soluble molecules in a solution. This separation is mainly based on the size of particles or molecules, but the permeability of membrane materials is also affected by the chemical, molecular, and charge characteristics of the sample. Ultrafiltration is usually used to separate molecules with a size difference of 3-5 times or more, and is not suitable for separating molecules with similar sizes.

Microfiltration (MF) is a process of separating soluble substances from large particulate matter (such as cell debris), which can significantly improve the clarity of the sample and reduce turbidity. Facilitating downstream processing in the future.

Modular system design:

Support linear amplification of film packaging from 0.11m ² (R&D) to 2.5m ² (production)
Sanitary grade fixture+clamp connection, quick disassembly and assembly in 15 minutes

High performance membrane packaging technology:

Membrane Material: Modified Polyether Sulfone (PESU)/Regenerated Cellulose (RC)
Key parameters:
▶ Molecular weight cut-off: 1-1000kD/0.22 μ m/0.45 μ m
▶ Import pressure: ≤ 4.2bar
▶ Transmembrane pressure (TMP): 4.5 bar (4-45 ℃)
▶ Chemical compatibility: pH 1-14, resistant to commonly used cleaning agents

Optional film packaging:

Selection guide for membrane packaging:

Applicable membrane area, processing capacity range, and fixture type
0.11m ² R&D/trial 200mL-2L stainless steel fixture (0.1m ²)
0.5m ² pilot 500mL-10L stainless steel fixture (0.5-2.5m ²)
1.3m ² pilot/production 10L-50L stainless steel fixture (0.5-2.5m ²)
2.5m ² production>50L stainless steel fixtures (0.5-2.5m ²)

Optional film packaging fixtures:

Diaphragm pressure gauge:

Sanitary diaphragm pressure gauge (accuracy ± 1% FS) real-time monitoring

Service support:

• Full cycle service: from URS writing → process optimization → cGMP compliant design

• Quality assurance: 100% integrity testing before leaving the factory (bubble point/diffusion flow)

• Technical training: Provide SAT/IQ/OQ validation and operation maintenance training

Application fields:

• vaccines

• monoclonal antibody

• recombinant protein

• plasmid

• Cell therapy, gene therapy

• Chemical medicine

• Traditional Chinese Medicine Injection

Typical applications:

• Clarification: such as separating cells/cell fragments

• Concentration: Protein concentration

• Desalination: desalination of nucleic acids, nanospheres, peptides, etc

• Buffer replacement: Changes in buffer system before and after chromatography

• Heat removal: removal of heat sources from culture media and traditional Chinese medicine injections