High voltage electrospinning and electronic injection method for preparing microsphere microcapsules device

MBE-3C is a device for preparing microsphere microcapsules using high-voltage electrospinning and electronic injection methodIt integrates a dual channel independent control injection pump, a high-voltage power supply, and a multi-purpose nozzle bracket. By applying a direct current high voltage to the microfluidic needle, the sprayed liquid particles form microspheres or microcapsules in the receiving phase. Composite nanoparticles with a core-shell structure can be prepared using coaxial electronic injection method. The electronic injection method has the advantages of short preparation cycle, low equipment cost, high encapsulation efficiency, and uniform particle size distribution. It is suitable for preparing single microspheres, core-shell multilayer microspheres, and particularly suitable for encapsulation of various drugs, proteins, and bioactive substances. Applied in biomedical applications such as tissue filling, cell and drug delivery, and minimally invasive tissue regeneration.

overall structure

*Overall design, the dual channel independent control injection pump, high-voltage power supply, and multi-purpose nozzle bracket are integrated together;

*The overall size is compact and can be placed on a desktop for use, or placed in a purification workbench or fume hood for work;

*The brackets in the work area are all insulated materials, and the nozzle is placed at the symmetrical center of the chassis, effectively ensuring uniform electric field;

*The workspace is spacious, with an electric lifting distance of up to 150mm for the nozzle, and strong expandability for experimental operations;

*Double opening polycarbonate transparent self-priming observation doors ensure safe experimental operation and facilitate real-time observation of experimental progress;

*Equipped with an emergency stop switch, it can quickly cut off power and relieve pressure in case of emergency;

Needles and stents

*Equipped with detachable double-layer coaxial needles as standard, it can be used for single needle experiments or core-shell double-layer experiments;

*Detachable design, the outer needle, inner needle, needle body seat, and connector can be easily disassembled and cleaned, solving the problem of difficult cleaning inside the welded coaxial needle head;

*Adopting a universal stainless steel needle holder, both the inner and outer needles can be replaced, suitable for various combinations of core-shell rulers

Exploration greatly reduces the cost of use;

*The main needle holder is made of 304 stainless steel material, which is corrosion-resistant; The adapter is made of medical grade PP material, which is clean and safe;

*Standard configuration includes one single-layer and one double-layer microsphere nozzle bracket, insulated material, which does not interfere with the electric field and can securely fix the high-voltage nozzle;

*The nozzle bracket is electrically adjustable and equipped with a ruler, making it easy to calculate and set the spraying distance;

ground loop

*Randomly attach 6cm, 8cm, and 10cm metal grounding rings to effectively confine the electric field and guide the microspheres to spray vertically downwards;

*The distance between the grounding ring and the nozzle, as well as the receiver dish, can be adjusted and is equipped with a ruler for auxiliary calculation, with a maximum adjustable distance of 10cm;

*The grounding ring fixing rod is equipped with 3 slots to ensure that grounding rings of different diameters are always concentric with the nozzle;

syringe pump

*Dual channel independent control for preparing core-shell composite microspheres;

*Specially optimized design for high-pressure electronic fuel injection, resistant to high pressure;

*The design of separating the nozzle and injection pump (PFA tube for spinning solution transmission) can prevent damage to the injection pump from electrostatic high voltage and extend the service life of the injection pump;

*High precision, ultra-low flow rate injection pump, stable operation, precise flow rate;

*Can support 2-20ml syringes of different specifications;

*Touch screen control, intuitive and convenient operation;

*Set fast forward/rewind buttons for easy loading and unloading of syringes, as well as for cleaning of pipelines and needles;

Customer Case

High voltage electrospinning and electronic injection method for preparing microsphere microcapsules deviceTechnical Specifications:

Nozzle type: Standard single needle nozzle and double-layer coaxial needle, 304 stainless steel, detachable, interchangeable needle

Nozzle lifting: electrically controlled

Maximum stroke of nozzle lifting: 150mm

Grounding ring: 1 6cm 8cm 10cm each

Adjustable range of distance between grounding ring and nozzle: 0-100mm with manual ruler

Number of injection pump channels: 2 channels independently controlled

Control mode: touch screen

Injection speed: 100 uL/h-7.62L/h

Maximum clamping syringe specification: 60ml

Output voltage: 0-+30KV continuously adjustable

Rated current: 1mA

Maximum output power: 30W

Voltage regulation rate:

Relative load: 0.01% (from no load to rated load).

Relative input: 0.01% (input voltage variation of ± 10%)

Current regulation rate: Relative load: 0.01% (from no-load to rated load)

Relative input: 0.01% (input voltage variation of ± 10%)

Ripple voltage: better than 1% rms at rated voltage

Magnetic stirrer: available

Disk diameter: 125mm

Blender speed: 200-1800rpm

Maximum mixing capacity: 1000ml

Magneton: Yes

Internal power socket: 1 220VAC;

Observation door: made of PC material, double opening self-priming

Power supply: 220V 50Hz

Power: 120W

Dimensions: W400 * D460 * H740mm

Weight: 15KG