Domestic replacement of Cultex cell exposure poisoning device

NegotiableUpdate on 05/07

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Overview

The domestically produced Cultex cell exposure poisoning device has been replaced, and in the fields of inhalation toxicology, respiratory disease mechanism research, drug safety evaluation, etc., the in vitro gas-liquid interface (ALI) exposure technology is becoming an important bridge connecting traditional in vitro experiments with in vivo animal models. This technology simulates the real physiological environment of human lungs - cells submerged in culture medium at the bottom and exposed to flowing airflow or aerosols at the top - allowing researchers to evaluate the biological effects of air pollutants, cigarette smoke, nanoparticles, drug aerosols, and other substances at the cellular level

Product Details

Domestic replacement of Cultex cell exposure poisoning device

In the fields of inhalation toxicology, respiratory disease mechanism research, and drug safety evaluation,In vitro gas-liquid interface (ALI) exposure technology is becoming an important bridge connecting traditional in vitro experiments with in vivo animal modelsThis technology simulates the real physiological environment of human lungs by immersing the bottom of cells in culture medium and exposing the top to flowing airflow or aerosols, allowing researchers to evaluate the biological effects of air pollutants, cigarette smoke, nanoparticles, drug aerosols, and other substances at the cellular level.

Domestic replacement of Cultex cell exposure poisoning device

Overview of Four Products

model	positioning	number of channels	Core Features
ACP3	Cellular dynamic exposure toxicity system	3	Large size compatibility : Supports 6-well, 12 well, 24 well plates and 35mm culture dishes (can be used for AMES experiments)
ACP6	Multi channel cell exposure poisoning device	6	Standard universal type 6-channel design, flexible setting of experimental and control groups, supporting 12 well and 24 well plates
ACP16	High throughput cell exposure poisoning device	16	High throughput+concentration gradient Each channel comes with a dilution inlet, allowing for arbitrary grouping for exposure to multiple concentration gradients
Mister	Cell static exposure poisoning device	9	Specialized for atomization Standard Aerogen atomization system, designed specifically for liquid atomized aerosols and precious samples

All four products share the following core technological advantages, which ensure the reliability and reproducibility of experimental results:

Radial symmetric distributed gas pathAll exposed cell compartments are distributed radially symmetrically, and aerosols are evenly distributed to each channel through the air inlet,Coefficient of variation of aerosol concentration and composition between channels: less than 5%
360 ° constant temperature and humidity controlConstant temperature of 37 ℃, temperature control accuracy ≤ 0.2 ℃ (Mistber ≤ 0.1 ℃), relative humidity ≥ 95%, simulating real respiratory environment
Independent liquid controlEach channel culture medium is independently supplied (0-10mL/min), supporting three modes: continuous, intermittent, and static
Fully automatic control softwareIntegrated airtightness testing, automatic addition and extraction of culture medium, experimental program editing, automatic cleaning and other functions
scalabilityCan be extended with QCM microbalance module for real-time monitoring of aerosol deposition quality
Widely applicable to various cell typesA549, HaCaT, CHO, Lk004, HFBE-21 and other commonly used cell lines can be used

Key Differences Comparison Table

comparative dimension	ACP3	ACP6	ACP16	Mister
number of channels	3	6	16	9
Applicable incubators	6-hole plate, 12 hole plate, 24 hole plate35mm culture dish	12 hole plate 24 hole plate	12 hole plate 24 hole plate	12 hole plate 24 hole plate
culture chamber	ACP3: The cultivation chamber has a larger size and consumes more culture medium per channel	The cultivation chamber has a smaller volume, which saves more culture medium
culture chamber	Independent control of culture medium in the cultivation chamber		Independent control of grouping of culture medium in the cultivation chamber
Aerosol exposure mode	Dynamic Flow (Continuous airflow passing through the cell surface)	Dynamic Flow	Dynamic Flow	Static settlement (Natural deposition of aerosols)
Core Features	Strong compatibility, supports large-sized culture dishes, can be used forAMES experiment	Standard 6-channel, balancing flux and cost	Each channel comes with a dilution inlet , can be setMulti concentration gradient(2-5 groups)	Standard Aerogen atomization system Specially designed for liquid atomization andPrecious samplesdesign
Aerosol flow control	5-30ml/min， Accuracy ≤± 1.5% F.S	5-30ml/min， Accuracy ≤± 1.5% F.S	5-30ml/min (aerosol+dilution air), accuracy ≤± 1.5% F.S	Not applicable (static settlement)
Temperature control accuracy	≤0.1℃	≤0.1℃	≤0.1℃	≤0.1℃
Typical application scenarios	Large scale cultivation experiment, AMES experiment, preliminary exploratory research	Conventional ALI exposure experiments require the establishment of an experimental group and a control group	Dose effect studies, high-throughput screening, and multi concentration gradient experiments	Liquid atomization exposure, evaluation of precious medicinal liquids, experiments requiring mild exposure conditions