Clinical mass spectrometry pre-processing automation workstation

1Clinical mass spectrometry pre-processing automation workstationBackground:

Sample preprocessing is a prerequisite step for most metabolomics, genomics, chemistry, and clinical experiments, and its quality directly affects the results of subsequent mass spectrometry analysis and data analysis.

At present, sample pretreatment is a key and difficult point in clinical mass spectrometry analysis, which restricts the improvement of mass spectrometry analysis efficiency and its wide application. According to data statistics, sample preprocessing accounts for over 60% of the entire process, and 32% of the errors come from the sample preprocessing stage.

IIClinical mass spectrometry pre-processing automation workstationCore parameters:

Three core modules:

1. Pipette device:

lTransfer range: 1-1000ul

l8通道high precisionpipetting

lCapable of achieving gradient dilution and mixing functions

lTransfer speed: required time ≤ 7min/96 wells;

lEquipped with liquid transfer calibration function, the system can automatically run liquid transfer volume calibration every six months

lMatch commonly used pipette tips in the market

2. Positive pressure nitrogen blowing:

lCleverly combining positive pressure with nitrogen blowing to save space

lPositive pressure: 0-100psi (adjustable at 0.5psi)

lNitrogen blowing: pressure 0-100psi (adjustable at 0.5 psi)

lGood airtightness and uniform air output

lEach nitrogen blowing needle can be individually controlled to save nitrogen loss

3. Heating oscillation：

lEffective oscillation speed up to 2500rpm/min (1r adjustable)

lAutomatic clamping of microporous plates, compatible with various types of orifice plates

lCan hold both upper and lower pieces for simultaneous oscillation

lHeating range: 30-85 ℃ (adjustable at 1 ℃)

3、 Product application:

Liquid chromatography tandem mass spectrometry (LC-MS/MS) is widely used in the screening of genetic metabolic diseases in newborns, vitamin detection, bile acid detection, catecholamine detection, homocysteine detection, drug concentration monitoring, hormone detection, microbial identification and other fields. Its application scenarios are broad. Therefore, to ensure accurate detection of the target object, it is crucial to automate the sample pre-processing process.

4productFeatures:

1. Efficiently completed the processing of 96 samples and 2 different projects within 1 hour;

2. Touch integrated operation interface, graphical user interface, free editing and processing program, can meet personalized experimental customization according to customer needs.

3. Clinical laboratory personnel can easily handle complex analysis of various clinical biological samples, solving the problems of low product automation, poor stability, and poor result consistency.

4. The system is suitable for commonly used pre-treatment methods in clinical practice, including protein precipitation, solid-phase extraction, liquid-liquid extraction, derivatization, and other methodologies.

5. Compatible with open pre-processing platforms and compatible with all commonly used LC-MS/MS systems in the market (AB Sciex, Waters, Thermo, Agilent, and Shimadzu);

6. Fully automated processing of metabolic target analyte samples (water-soluble vitamins, fat soluble vitamins, amino acids, newborn screening, bile acid, hormone and other metabolite and drug concentration detection (TDM), etc.). Provide a complete solution for clinical mass spectrometry detection, achieving automation and standardized operation of mass spectrometry sample processing.

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