Applichem | N, N-dimethylacetamide (DMAC)

Applichem | N, N-dimethylacetamide (DMAC)

N. N-Dimethylacetamide (DMAC or DMA), with the chemical formula CH3 C (O) N (CH3) ₂ and a molecular weight of 87.12 g/mol, is a colorless and transparent liquid commonly used as a non-polar solvent; It can be miscible with various organic solvents such as water, ether, ketone, alcohol, benzene, ester, etc., and is therefore widely used as a reaction solvent and process medium.

In the biopharmaceutical process, dimethylacetamide has various applications, mainly reflected in the following aspects:

1. Drug synthesis and intermediate preparation

DMAC is commonly used as a solvent or co catalyst in the synthesis of antibiotics (such as amoxicillin and cephalosporins) and anti-tumor drugs, which can improve reaction yield and product purity. In organic synthesis, DMAC is widely used for the construction of drug intermediates, especially for the synthesis of hydrophobic drug molecules, by reducing the activation energy of the reaction and promoting efficient reaction.

2. Preparation of Antibody Conjugated Drugs (ADCs)

In the coupling process of ADC, DMAC is often used as a co solvent to dissolve hydrophobic cytotoxic drug payloads, thereby improving their coupling efficiency with antibodies; When combined with surfactants, a micelle structure can be formed, enhancing the solubility and reaction selectivity of the load, ensuring efficient and specific connection between the antibody and the load.

3. Drug formulation development

In co precipitation technology, DMAC is used as a good solvent to dissolve drugs and polymer carriers, forming amorphous solid dispersions (ASD) through rapid evaporation (or "solvent evaporation"), thereby improving the solubility and bioavailability of poorly soluble drugs. DMAC can also be used to prepare film formulations, microcapsules, and other preparations, achieving sustained release or targeted delivery of drugs due to its good solubility and film-forming properties.

4. Protein and nucleic acid related processes

DMAC can serve as a solvent to help dissolve and stabilize biomolecules during protein purification, nucleic acid extraction, and other processes, reducing non-specific binding and degradation; In certain enzymatic or nucleic acid synthesis reactions, DMAC can also provide a suitable solvent environment to facilitate the reaction.

The application of DMAC in biopharmaceuticals requires strict control of its purity, moisture, and impurity content to ensure the quality and safety of the drug. At present, neither the United States Pharmacopeia (USP) nor the Chinese Pharmacopoeia (ChP) contains pharmaceutical quality standards for DMAC, and pharmaceutical DMAC mainly refers to the standards of the European Pharmacopoeia (Ph. Eur.). As a high-quality pharmaceutical raw material supplierPanReach AppliChem provides stable, high-quality DMACs that comply with the European Pharmacopoeia for biopharmaceutical companies. It offers * regulatory document support, high purity (≥ 99.0%), low moisture and impurity content, and strict control over metal element impurities. It meets the ICH Q3D standard and can reduce the impact of impurities on chemical reactions and final product quality, thereby improving process stability and drug safety. It is very suitable for the research and production of biopharmaceuticals such as antibody conjugated drugs (ADCs).

Applichem | N, N-dimethylacetamide (DMAC)

Product Information

PanReach AppliChem's pharmaceutical grade N, N-dimethylacetamide (DMAC) can provide free samples. WelcomeApply for testing, limited quantity, first come, first served!

PanReach AppliChem is one of the high-quality producers of biochemical reagents and pharmaceutical raw materials from Europe, with a century long history and multiple ISO quality system certifications. It is an important supplier to life science research, CRO/CDMO enterprises, large pharmaceutical, diagnostic, food, cosmetics and other industrial enterprises. As a long-term fixed supplier to multiple culture medium manufacturers and pharmaceutical companies, PanReach AppliChem is one of the few production enterprises that can provide numerous pharmacopoeia grade and cell culture grade raw materials. It comprehensively offers cell culture grade, pharmacopoeia grade, biochemical grade, ultra pure grade and other chemicals, including culture medium components such as amino acids, vitamins, antibiotics, salts, buffers, stabilizers, surfactants, and commonly used chemicals in pharmaceutical processes such as Tris, guanosine, adenine, sodium caprylate, etc DMSO、 Glucan, etc.

Ximeijie is the general agent of PanReach AppliChem in China, providing customers with * technical support and after-sales service.Beijing Ximeijie is the agent of Applichem, the agent of Applichem in China, the agent of Applichem in Beijing, the general agent of Applichem, and the agent of Applichem in Shanghai, ， Applichem Northwest Agent, Applichem Southwest Agent, Applichem Northeast Agent, Applichem North China Agent, Applichem South China Agent, Applichem Central China Agent, responsible for Applichem's related business in China.