Aging test box - a good helper for cosmetics and drug aging testing

The aging test chamber - a good helper for cosmetics and drug aging testing LUYOR-3450 is exquisitely designed and structurally simple. Following OECD, EU, GB/T standards, it can automatically complete various testing experiments and in vitro identification experiments for cosmetics, chemical raw materials, etc. with potential phototoxicity. Cytotoxicity refers to the adverse reactions and even death caused by chemical substances acting on the basic structure and/or physiological processes of cells, leading to disruption of cell survival, proliferation, and/or function. The phototoxicity of cells refers to the excitation of certain chemicals to an excited state under certain wavelengths of light, which exhibits toxicity and killing

3T3 NRU cells subjected to phototoxic irradiationInstrument LUYOR-3450

The aging test chamber - a good helper for cosmetics and drug aging testing LUYOR-3450 is exquisitely designed and structurally simple. Following OECD, EU, GB/T standards, it can automatically complete various testing experiments and in vitro identification experiments for cosmetics, chemical raw materials, etc. with potential phototoxicity. Cytotoxicity refers to the adverse reactions and even death caused by chemical substances acting on the basic structure and/or physiological processes of cells, leading to disruption of cell survival, proliferation, and/or function. The phototoxicity of cells refers to the exposure of certain chemicals to certain substanceswavelengthUnder the illumination of a light source, it is excited to an excited state, which exhibits toxicity and kills cells or triggers cell specific changes.

In daily life, many drugs or cosmetics used in daily life do not cause direct harm to the human body or organisms, but they can be activated under conditions such as sunlight or ultraviolet environment, causing harm to the human body or organisms and triggering some diseases. Therefore, manufacturers need to test the in vitro cell phototoxicity of the selected substances in the process of developing and designing drug or cosmetic ingredients. And for a long time, people have been troubled by some cellular carcinogenesis or hyperplasia diseases such as cancer and tumors. Currently, researchers in the medical field have also found that some drugs produce excited states under light that have phototoxic effects on specific cancer cells. That is, drugs (or photosensitizers) are first aggregated on the cancerous or tumor lesions, and then specific wavelengths of laser are used to irradiate these cancerous or tumor lesions, activating the drugs gathered here and causing photochemical reactions to damage or kill the cells, thereby achieving therapeutic effects. Therefore, in the process of drug development, in vitro cell phototoxicity testing has become a very necessary testing item for medical workers. However, the existing cell phototoxicity testing equipment is bulky, inconvenient to transfer, and not suitable for small-scale cell phototoxicity testing experiments. In addition, the light source of the existing phototoxicity testing equipment emits light unevenly, and the on/off time of the light source equipment cannot be controlled regularly, requiring manual operation. Therefore, LUYOR has developed a flexible and convenientAging test box - a good helper for cosmetics and drug aging testingLUYOR-3450.

Photothermal therapy relies on light to activate the biological toxicity of drugs (photosensitizers or photothermal materials) to kill cancer cells, viruses, bacteria, fungi, etc. In order to develop new photosensitizers and photothermal materials, researchers often require a large amount of in vitro cell illumination experimental data to evaluate the efficacy of these drugs. The cell phototoxicity radiometer LUYOR-3450 provides a light source for various experiments such as cell illumination, high-throughput photocatalysis, and photo induced deformation.

Performance advantages of LUYOR-3450 and traditional solar simulators:

1. Low power operation does not generate a large amount of heat. The LUYOR-3450 has a full power of only 60W, while most solar simulators have a power of 500W

2. UVA lamp, without UVB damage, the solar simulator emits a certain amount of UVB energy

3. Equipped with a high-precision ultraviolet sensor, there is no need to purchase an additional UV lux meter.

4. Set the energy value, run automatically, end irradiation, and stop automatically. No need for manual supervision.

5. The factory set light intensity is 1.7-1.9mW/cm2, without the need for tedious lamp adjustments.

6. Safety structure door lock, automatically turns off the ultraviolet light source when opening the door, and has no ultraviolet radiation to the operator and surrounding personnel.

7. The lifespan of the light source is approximately 5000-8000 hours, which is 5-10 times that of traditional solar simulators.

8. Compatible with standard 96 well cell culture plates

Technical parameters of 3T3 NRU cell phototoxicity irradiation instrument LUYOR-3450

1. Power supply: 220 VAC, 50 Hz

2. Capacity: 2 standard 96 well plates

3. Fixed program: UVA intensity of 1.69 mW/cm2 for 50 minutes

4. UVA irradiation intensity range: 1.3 mW/cm2 to 2.5 mW/cm2;

5. Light source system: 4 365nm 8W ultraviolet lamps

6. Radiation chamber: width 26cm, depth 32cm, height 15cm

7. Built in 365nm ultraviolet sensor for detecting ultraviolet radiation energy.

8. Sensor accuracy:±5%

9. Microprocessing control, capable of independently setting irradiation energy and irradiation time.

10. The sensor collects data 5 times per second, and the CPU calculates the remaining irradiation energy in real time.

11. UV irradiation energy setting range: 0.025-99.99J/cm2,

The time setting range is 0-599.5 minutes.

13. Dual fan cooling, irradiation chamber temperature below 37 degrees.

3T3 NRU cell phototoxicity irradiation instrument LUYOR-3450 application areas

Cell phototoxicity: suitable for photothermal therapy and photothermal therapy, evaluating the cell phototoxicity of photosensitive drugs

Photoinduced drug release: using light to control photosensitive drugs and achieve controlled drug release

UV curing: UV LED light sources can be applied in fields such as UV curing resin forming, UV curing adhesives, UV curing coatings, UV curing inks, etc

Photoinduced deformation: developing new types of photo induced deformation materials using photochemical and photophysical effects

Photogenetics: Utilizing light to control photosensitive proteins and demonstrate cellular activity

High throughput photochemical reactions: suitable for photocatalyst development and photochemical synthesis reaction conditionsFilter

The LUYOR-3450 radiometer is a light source reactor that allows for the selection of multiple frequency bands. Customizable 254 nm、302nm、365nm、395nm，400nm，420nm、455nm、480nm、505nm、555nm、660nm、760nm Waiting for multiple frequency bands. The LUYOR-3450 irradiator in the 254nm, 302nm, and 365nm wavelength bands has four 8W ultraviolet light tubes inside, with built-in ultraviolet sensors that can control the energy of ultraviolet radiation.

The LUYOR-3450 radiometer with wavelengths of 395nm, 400nm, 420nm, 455nm, 480nm, 505nm, 555nm, 660nm, and 760nm can be optionally equipped with 24 high-power 3W LEDs for single or multi band irradiation, with an adjustable irradiation power of 10%.

The LUYOR-3450 radiometer is equipped with a fan cooling system to ensure the temperature of the reaction chamber. The irradiation chamber is made of mirror stainless steel, and the irradiation inside the reactor is uniform.

The LUYOR-3450 radiometer adopts microprocessor control and can set the irradiation time, which can be set from 0 to 999.5 minutes.