A must see for novice researchers! 5 '- azido NHS Ester Beginner's Guide

Chemical structure:

5 '- Azido NHS Ester is a compound containing azide groups (- N3) and NHS active ester groups. The azide group can be used for click chemistry reactions, while the NHS active ester group can react with primary amines (- NH2) on biomolecules to form stable amide bonds.

Packing:

Overview of Basic Knowledge:

A must see for novice researchers! 5 '- azido NHS Ester Beginner's Guide

Chinese name: 5 '- azido NHS Ester

English name: 5 '- azido NHS Ester

Specification standards: 1mg, 5mg, 10mg

Reagent manufacturer: Shaanxi Xinyan Bomei Biotechnology Co., Ltd

Related applications:

1. Biomolecular markers:

It can be used to label biomolecules such as proteins, peptides, nucleic acids, etc. After introducing azide groups, it can be further coupled with other compounds through click chemistry reactions.

For example, reacting with alkynyl markers to form stable 1,2,3-triazole rings.

2. Click on Chemistry:

The azide group can undergo copper catalyzed azide alkyne cycloaddition reaction (CuAAC) with alkyne compounds, as well as copper free click chemical reaction (SPAAC) with strain promoted alkynes (such as DBCO).

3. Drug development:

As a PROTAC (protein degradation targeted chimeric) linker, used for synthesizing PROTACs.

Used for synthesizing antibody conjugated drugs (ADCs).

Notes:

Purity standard 95%+

Storage suggestion: Avoid repeated freeze-thaw cycles, store in the dark, use the stored solution immediately, and divide any unused solution into small portions and freeze at<-20 ° C

Caution: For scientific research only

Related reagents (partial):

Azido-dPEG 4-NHS ester

Azido-PEG6-NHS ester

6-Azidohexanoic Acid NHS Ester

N3-C5-NHS

PC Azido-NHS Ester

Azido-PEG3-O-NHS ester

N-(Azido-PEG4)-N-Boc-PEG4-NHS ester

PC Azido-PEG11-NHS carbonate ester

Azidobutyric acid NHS ester

Azido-PEG24-NHS ester

Azido-PEG5-NHS ester

A must see for novice researchers! 5 '- azido NHS Ester Beginner's Guide