Parallel synthesis reactor is a commonly used instrument in the field of chemical synthesis, which can simultaneously perform multiple parallel reactions and improve experimental efficiency. The following is an introduction to its structural composition and product features:
structural composition
Reaction module: It is the core part of a parallel synthesis reactor, usually composed of reaction blocks and reaction tubes. The reaction block has a circular design and can accommodate multiple reaction tubes. For example, the Solid16 reaction block can accommodate 16 reaction tubes, each with a capacity of 42ml. The reaction tubes are generally made of transparent PTFE or PFA materials and have chemical corrosion resistance. The bottom is equipped with a filter, valve, and connecting tube for the collection box, and the upper part is equipped with a separator and connecting tube for vacuum and inert gas.
Temperature control system: used for precise control of reaction temperature. Some instruments have multiple independent temperature control zones, which can simultaneously set different reaction temperatures. For example, some instruments have four independent temperature control zones. The temperature control range is generally from room temperature to 180 ℃, and a low-temperature module can be optionally selected, with a minimum temperature of -78 ℃.
Stirring system: Magnetic stirrers are usually used to provide heating and stirring for multiple reactors, ensuring the parallelism of the experiment. For experiments with high viscosity or crystallization, some instruments can also be equipped with an overhead stirring module, which can use the same overhead stirrer to mechanically stir multiple reaction sites simultaneously.
Gas path system: The instrument is equipped with a centralized gas path at the top, which can simultaneously or separately evacuate or fill each reaction site with inert gas to meet the requirements of different reactions for the atmosphere.
Feeding system: used to inject reactants into each reaction vessel, usually using micro pumps or micro nozzles to ensure precise feeding and uniform mixing.
Detection system: Some parallel synthesis reactors are equipped with detection systems to monitor the generation of products and consumption of reactants during the reaction process. Common detection methods include mass spectrometry, infrared spectroscopy, and high-performance liquid chromatography.
Waste liquid collection system: composed of waste liquid tank, test tube, and test tube rack, used to collect washing solvents and reaction products. After synthesis, the products can be collected in the test tube by vacuum.
Product Features
Efficiency: Multiple parallel reactions can be carried out simultaneously, greatly reducing experimental time and improving synthesis efficiency. It is suitable for fields such as combinatorial chemistry synthesis and drug development that require a large amount of synthesized compounds.
Good parallelism: Using the same stirrer or overhead stirrer to stir multiple reaction sites, with uniform temperature control, can ensure that each reaction proceeds under the same conditions, resulting in good parallelism and repeatability of experimental results.
Easy to operate: The reaction tube often adopts a screw cap design, which is easy to clean and replace the filter membrane. The valve reaction tube does not require the use of a sampling needle, and sample processing is fast and easy.
Accurate temperature control: Equipped with a precise temperature control system, high temperature accuracy, and some instruments can independently control temperature in multiple areas, which can meet the demanding temperature requirements of different reactions.
Strong compatibility: It has multiple types such as tube and flask, and can be compatible with reaction containers of different volumes. For example, the 12 position tube parallel synthesizer is suitable for reactions of 1-20ml, and the 6-position flask parallel synthesizer can be compatible with round bottom flasks of 5-250ml per site.
High safety: Some instruments come with protective covers, and the waste collection box has a transparent glass door that allows for full observation of the reaction process. At the same time, vacuum or inert gas connections are centralized, reducing safety hazards during experimental operations.