Since the first generation in 2013, based onQuadrupole rod、ion trapandThree in One Mass Spectrometry of Orbitrap Mass AnalyzerThe three in one mass spectrometry, which combines ultra-high resolution, sensitivity, stability, and various extended functions, has gained widespread attention in the industry and greatly driven new applications and understanding in fields such as life sciences.

withOrbitrap™ Ascend™andOrbitrap™ Eclipse™The new generation of three in one mass spectrometry family, represented by, aims to address the diverse challenges in life science research while continuously improving overall performance and ease of useProteomic identification, quantitative proteomics, structural biology, biopharmaceutical analysis, and research on small molecule complex samplesShow more potential applications.

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Innovate and inherit classics, explore the ultimate goodness

Figure 1 Schematic diagram of the internal structure of Orbitrap Ascend three in one mass spectrometer

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Innovation Highlights:

（1）Adopting gentler ion funnel technology to reduce the source cracking level of fragile substances, improve detection limits, and reduce false positives;

（2）Newly added multi-stage ion channels before C-Trap for conventional ion storage and MS2 fragmentation, improving sensitivity and scanning speed; The subsequent multi-level ion channels are still used for CID, ETD, UVPD, PTCR, and MS HCD, maintaining the multifunctionality of the system;

（3）Adopting a new transmission module to improve the efficiency of high-quality ion transmission, the scanning range of ions has been expanded to m/z 16000 (optional HMR ⁿ+mode);

（4）A brand new automatic calibration ion source, with custom calibration time and cycle, the instrument automatically performs calibration to maintain the system in the best performance state;

Beyond fixed thinking patterns, expanding research perspectives

Complex of Diversity[①], is one of the essential attributes of contemporary scientific research, andThree in one mass spectrometryBased on breakthroughs in various fragmentation modes and innovative technological combinations, the diversity of science is fully demonstrated: whether it is providing accurate and precise quantification of low abundance peptides in complex matrices, or characterizing structural isomers from drug metabolites to intact proteins, as well as distinguishing isotopic species and characterizing natural protein complexes.

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believeOrbitrap Ascend Tribrid Mass SpectrometryandOrbitrap Eclipse Tribrid Mass SpectrometryThe new generation of three in one mass spectrometry family can provide more flexible and powerful functions, greatly helping to broaden research horizons, enhance the depth and breadth of research, and expand diverse research fields such as life sciences, structural biology, pharmaceuticals, food, and environment to achieve more breakthroughs from scratch.

[①] M. Gibbons, et al. The New Production of Knowledge. SAGE Publications Ltd, 1994, p.2.

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