Small molecule drugs mainly refer to chemically synthesized drugs, usually organic compounds with a molecular weight of less than 1000. Small molecule drugs have the advantages of wide application and mature theory. The structure of small molecule drugs has good spatial dispersion, and their chemical properties determine their excellent drug properties and pharmacokinetic properties. These characteristics make small molecule drugs show great advantages in the drug development process and other drug fields, and the development of small molecule drugs is increasingly favored by the market. However, the easy aggregation of small molecule drugs hinders subsequent research and development processes, requiring the use of microjet homogenizers for dispersion to reduce the average particle size and PDI of drug particles.
We first used a small high shear machine and a peristaltic pump to form an online shearing system, which sheared small molecule drugs and solvents for 20 minutes under continuous circulation conditions for initial dispersion. The F20Y type jet diamond interaction chamber was installed on the MiniDeBEE45 micro jet homogenizer in the United States, and the initially dispersed drug solution was subjected to multiple micro jet homogenization at 30000 PSI. From the particle size test report below, it can be seen that the average particle size of the main peak after five rounds of homogenization has reached 151.8 nm, while after 15 rounds of homogenization, the average particle size of the main peak has decreased to 94.17 nm, and the total average particle size has reached 72.82 nm. The particles at the tail end of about 4 μ m can be filtered through a filter membrane.

Dispersion of small molecule drugs using a microjet homogenizer for 5 particle size distributions

Dispersion of small molecule drugs using a microjet homogenizer for 15 particle size distributions
The jet diamond interaction chamber used in this experiment is a new generation of ultra-high pressure homogenization chamber developed by the American company Genizer. It uses supersonic material fine streams to collide with each other, generating extremely strong shear effects to improve the emulsification, uniformity, and stability of the material, refine particle size, and narrow distribution. MiniDeBEE45 is the core product of BEE Corporation in the United States, an ultra-high pressure micro jet homogenizer. The equipment is designed with a pressure of 45000PSI (300Mpa) and a flow rate of 22L/H. It can be used as a homogenizer for emulsions, liposomes, suspensions, dispersions, cell lysis, cosmetics, and materials in small-scale trials.