Scientific research exploration never stops, technological innovation welcomes a new chapter! Grober Biosciences has officially become the Chinese agent for the NeuralGlider Inserter neural implant ultrasonic thruster and SonoShield Defender electrode ultrasonic shield under Activated Neuroscience, bringing new tools to researchers!
Improving implantation accuracy while reducing force - NeuralGlider Inserter
In neuroscience research, the accuracy of nerve implantation is crucial for obtaining high-quality data and gaining a deeper understanding of neural mechanisms. The NeuralGlider Inserter utilizes ultrasonic micro vibration technology to break through the limitations of traditional implantation, significantly reducing the force and indentation during implantation, allowing neural implants such as electrodes/Lens/fiber optic sleeves to enter the target area more gently and accurately.
The linear motor equipped with it can accurately control the insertion depth and speed, ensuring that the ideal position is achieved every time it is implanted; The low profile microscope camera provides real-time assistance for observation, making the surgical field of view clear and visible; It can also adapt to standard stereo positioning frameworks, providing a stable foundation for operation. From the data, it can be seen that it has increased the insertion speed of Neuropixels 2.0 probes by 8 times, and the speed of UNC flexible probes by 2000 times. It not only improves the accuracy of electrode placement, but also greatly reduces the formation of chronic glial cells, laying a solid foundation for long-term stable neural recording. It has been verified and praised in multiple studies!
Creating a protective sound field and extending electrode lifespan - SonoShield Defender
Electrodes face many challenges in chronic use, such as foreign body reactions and encapsulation by microglia, which often lead to decreased electrode performance and shortened lifespan. SonoShield Defender utilizes a focused sound field to create a neuroprotective environment around implanted electrodes, addressing these challenges at their root.Low intensity pulsed ultrasound stimulation (LIPUS) increased the migration speed of microglia by 128%, expanded the area by 109%, and reduced activation by 17% in the first week of treatment, significantly reducing the coverage of microglia on microelectrodes and scar formation of astrocytes, allowing the electrodes to work stably for a long time. Research has shown that it can effectively improve electrode performance, such as increasing signal-to-noise ratio and enhancing single unit detection capability. It performs well in reducing foreign body reactions around chronic cortical microelectrodes, bringing new hope to the field of neural therapy!
Imaging comparison: Representative two-photon images after 14 days of implantation showed that in the control group, microglia were widely covered on the electrode; In the SonoShield group, the morphology of microglia was significantly different, and the overlapping of their protrusions was reduced.
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