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Bruker NanoCT Empowerment! The research achievements of bionic gel hemostasis were listed in Nano Lett
Date: 2025-07-11Read: 0
XRM Application Articles
Bruker NanoCT Empowerment!
The research achievements of bionic gel hemostasis were listed in Nano Lett
Introduction
Recently, a research paper titled "Centrifugal Spinning Driven Biomimetic Aerogel for Rapid Hemostasis with Minimal Blood Loss" was publishedInternational Journal Nano Lett(2025, 25, 6040-6050) Published. The first author of this article is Fu Fen, a doctoral student at the School of Textiles, Donghua University. The corresponding authors are Professor Wang Fujun, Professor Zeng Yongchun, and Professor Zhao Fan, a specially appointed researcher at the School of Textiles, Donghua University. Focusing on the major needs in the field of emergency hemostasis, this research successfully developed a bionic fiber aerogel based on centrifugal spinning technology, providing a new solution for rapid control of massive bleeding. In the material characterization process of this study, the authorUsing the Brooke Nanoscale 3D X-ray Microscope (NanoCT) SkyScan2214 CMOSThe 2D imaging, 3D reconstruction and stick model simulation obtained from the test clearly observed and analyzed the highly interconnected porous structure in the aerogel, which provided an important microstructural basis for understanding its excellent water absorption and hemostasis performance. The author also stated at the end of the article thatShuyun Instrument (Shanghai) Co., LtdMr. Ding Hao expressed his gratitude for his professional support and assistance in the testing and analysis of nano CT
Abstract
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Research background: The urgent need for the treatment of massive bleeding
Massive bleeding is one of the main causes of death in trauma patients. Whether in civilian or military settings, hypotension and multiple organ failure caused by blood loss often significantly increase mortality rates. The human body's own coagulation mechanism often struggles to cope with deep trauma or coagulation dysfunction, therefore,Developing advanced hemostatic materials that can shorten hemostasis time and reduce blood loss has become an urgent task.
Although existing commercial hemostatic materials can play a role to some extent, there are still shortcomings in dealing with complex wounds and large-scale injuries. For example, some materials have poor pore connectivity, which affects liquid absorption and permeation efficiency; Some materials have limited volume expansion and liquid absorption capacity, which may lead to prolonged hemostasis time and increased blood loss.
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Core achievement: Integration of biomimetic design and advanced technology
The research team was inspired by the root hair structure and prepared a special material using centrifugal spinning technologyMicrostructure aerogels (CTBs)This aerogel is composed of grooved cellulose acetate (CA) fibers and folded thermoplastic polyurethane (TPU) fibers, which are crosslinked by blocked aqueous isocyanate (BIC) to form a three-dimensional network, and its pore connectivity is as high as 99.99%.
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Figure 1
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passSkyScan2214 CMOSImage characterization of the interconnected porous structure of CTBs-6.0 simulation, including two-dimensional images, three-dimensional reconstructed images, and ball stick models (balls represent pores, sticks represent channels connected to pores)
Centrifugal spinning technologyThe application of this technology is a major highlight of the study, with production efficiency far exceeding that of electrospinning technology (over 1000 times), laying the foundation for the large-scale preparation of materials. By regulating the phase separation during the spinning process, the research team successfully formed groove structures on the surface of CA fibers and wrinkled structures on the surface of TPU fibers. These microstructures help enhance the adhesion and infiltration of blood cells, accelerating the coagulation process
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Performance advantages: hemostatic effect and biological properties相容性
The experimental data show that the aerogel has high porosity (92%) and excellent water absorption (4147 ± 99%), and low blood absorption (1210 ± 17%),It can quickly activate the coagulation cascade reaction and achieve efficient hemostasis.
In in vivo model experiments of rat tail amputation, liver injury, and nephrectomy, compared with commercial hemostatic materials such as cotton, gelatin sponge, and gauze,The aerogel can reduce the amount of blood loss by about 94% and the time of hemostasis by about 78%, showing significant advantagesIn addition, the aerogel also has good biocompatibility, and the hemolysis rate is extremely low (0.01 ± 0.033%), in line with international standards; Its excellent mechanical properties and shape recovery ability enable it to adapt to wounds of different shapes, apply appropriate pressure to promote hemostasis, and are particularly suitable for complex trauma scenarios.
Disclaimers
The content of this article is based on research papers published in Nano Lett. (2025, 25, 6040-6050). The mentioned research results are still in the laboratory stage and their clinical applications need further validation. This article is only for academic exchange and information sharing purposes and does not constitute any medical advice or product recommendation.