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Working process of gas chromatography-mass spectrometry
Date: 2025-12-03Read: 0

Gas chromatography-mass spectrometerGC-MS is an analytical instrument that combines the efficient separation capability of gas chromatography (GC) with the precise identification capability of mass spectrometry (MS).

Gas chromatography-mass spectrometerCompounds in complex samples are separated by gas chromatography, and the separated components are ionized and analyzed by mass spectrometry. Qualitative and quantitative analysis is then achieved through mass to charge ratio (m/z). The specific process is as follows:

Sample separation: The sample is separated by a gas chromatography column, and different compounds are separated in the column due to differences in distribution coefficients.

Ionization process: The separated components enter the ion source and are ionized into charged ions.

Quality analysis: Ions enter the mass analyzer and are separated according to the mass to charge ratio.

Detection and data processing: The detector converts the ion signal into an electrical signal, which is processed by a computer to generate a mass spectrum. It is then quantitatively analyzed using a spectral library or standard samples.

Main advantages:

Combining the strong separation ability of gas chromatography and the high identification ability of mass spectrometry, it can effectively separate and detect complex compounds.

High sensitivity, capable of detecting trace substances.

The real-time acquisition function provides data acquisition for both full scan and selective ion scan, which can obtain accurate qualitative and quantitative results.

Application fields:

Environmental monitoring: It can detect volatile organic compounds (VOCs) in the air, pesticide residues in water, polychlorinated biphenyls and other organic pollutants.

Food Safety: Used for detecting pesticide residues, veterinary drug residues, additives, preservatives, volatile organic compounds, and other components in food.

Other fields: it is also widely used in the detection of harmful substances in the electronic industry, the analysis of aroma components in the essence and fragrance industry, drug research and development in the pharmaceutical industry and other fields.