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Case study on the analysis and solution of droplet size of fusidic acid ointment
Date: 2025-08-26Read: 0


夫西地酸softAs an external antibiotic, ointment usually has the effects and functions of antibacterial and anti-inflammatory, inhibiting bacterial protein synthesis, treating skin bacterial infections, relieving local redness and pain, and preventing the spread of infections. Fuxidi yogurt cream can exert antibacterial effects by inhibiting the synthesis of bacterial proteins, preventing bacterial growth and reproduction. It has a strong inhibitory effect on gram-positive bacteria such as Staphylococcus aureus and Staphylococcus epidermidis, and can alleviate skin inflammatory reactions.

The particle size and particle size distribution of ointment are important indicators for measuring the quality of products. If the particle size range isIf controlled reasonably, there may be inconsistencies in dissolution and absorption between batches, large fluctuations in curve peaks and valleys, which may lead to safety issues or an increase in adverse reactions.

For milkdropIn addition, the droplet size should also be observed. Droplets can coagulate, coalesce, or undergo Ostwald ripening, thereby changing their size and shape. The most common API or droplet size measurement technique is optical microscopy, where droplet size can be manually measured using a calibrated standard ruler, or measured using instruments equipped with imaging systems and analysis software.

The imaging effect of ordinary microscopes is poor, making it difficult to distinguish between sample matrix and droplet size, and unable to provide effective and statistically significant particle size distribution values. It also requires manual measurement with a standard ruler, greatly increasing measurement efficiency and accuracy.

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The YH-MIP-0982 microscope particle size analyzer independently developed by Yinhuang Technology is specifically designed for detecting particle size and particle size distribution of external formulations. The equipment has the characteristics of intuitive, visual, accurate, wide testing range, simple operation, and multiple measurement parameters.MIP-0982-3组合带电脑分析画面

Adjust YH-MIP-0982 particle size analyzerAfter reaching the optimal field of view of the sample, use analysis software to capture images, identify particles in the images, measure them using imaging systems and analysis software, and automatically and quickly analyze the number of particles in the field of view, providing key data such as particle size, average particle size, D10/D50/D90 (adjustable), morphology, etc. The software meets the requirements of 21CFR Part 11 and GMP for data integrity.