The blade type freeze grinding homogenizer is a commonly used equipment for processing heat sensitive substances, such as biological products, pharmaceutical products, etc. It combines freezing technology with mechanical grinding to achieve efficient homogenization and grinding effects, and is commonly used in high-value, high-precision product processing. The process principle can be understood from three main processes: freezing, grinding, and homogenization.
Process principle of blade type frozen grinding homogenizer
1. Freezing process
Low temperature freezing medium: Liquid nitrogen or other low-temperature freezing medium is often used inside the equipment to quickly cool the material to a low temperature state before processing. The purpose of cooling is to prevent thermal degradation or property changes of thermosensitive substances (such as fats, proteins, drugs, etc.) during the processing.
Cooling objective: To make the material reach a brittle state, reduce material degradation caused by high temperature during processing, and avoid adhesion of viscous materials, ensuring fluidity and processing effectiveness.
Freezing temperature: The temperature during the freezing process is generally between -60 ° C and -150 ° C, adjusted according to different materials and process requirements to ensure that the materials have good mechanical properties.
2. Grinding process
High speed rotation of blades: In the frozen state, the material is sent into the grinding area, and the blades rotate at a high speed. Through mechanical force, the material undergoes multiple actions such as shearing, compression, and stretching, resulting in material breakage.
Material crushing: The frozen material is subjected to high-speed shearing by grinding blades due to its brittleness, decomposing into small particles or powders. The shear and impact forces of high-speed blades enable efficient crushing of large materials into smaller particle sizes.
Efficient grading: By adjusting the working parameters of the grinding device (such as blade speed, material feeding speed, etc.), the particle distribution and size of the material can be effectively controlled.
3. Homogenization process
Homogenization effect: The blade type frozen grinding homogenizer ensures uniform particle distribution of the crushed material by passing it through a specific aperture or sieve. Homogenization helps to improve the consistency of the final product, especially in processes such as emulsification and dispersion.
Material recycling: During the processing, some materials may be recycled back to the grinding chamber, further reducing particle size and improving homogenization efficiency.
4. Discharge and Collection
The material that has been ground and homogenized is ultimately discharged through the outlet and collected into the designated container. This process can be synchronized with the cooling system to ensure that the properties of the product will not change due to temperature rise during the collection process.
Process Characteristics
Low temperature treatment: This process is particularly suitable for thermosensitive materials, such as biomolecules (such as proteins, enzymes), drug carriers, food raw materials, etc., avoiding degradation caused by heat.
Efficient Grinding: By providing strong shear and impact forces through high-speed rotating blades, it can handle hard and brittle materials, ensuring efficient grinding results.
Uniform dispersion: Ensure the fine particles and uniform distribution of the material, suitable for precision machining needs.
Application field
Biological product processing: such as vaccine preparation, antibody preparation, etc.
Drug production: especially in the process of drug micronization and powdering.
Food industry: such as processing of dairy products, crushing of seasonings, etc.
Chemical industry: grinding of pigments and chemical catalysts.
This process combines the advantages of freezing technology and mechanical grinding to efficiently and gently process complex substances, especially suitable for temperature sensitive raw materials.