Introduction

Hydrochloric acid dechlorinated hydroxyzine is a derivative of the * generation antihistamine hydroxyzine, which has a strong H1 receptor selective blocking effect and a long duration of action, maintaining therapeutic efficacy for 6-12 hours. Promethazine hydrochloride is a phenothiazine antihistamine drug that can be used for antiemetic, anti motion, and sedative hypnotic purposes.

Parallel liquid chromatography is equivalent to one liquid chromatography that can be used as two liquid chromatography functions, sharing one automatic sampler and column temperature box; Includes one set of dual ternary gradient pumps, providing two independent flow path systems, each system providing three analytical mobile phase channels; Two detectors, which can be of the same type or of different types. Therefore, the system can run two different analysis methods simultaneously, which can increase the analysis throughput of samples and improve method development capabilities without the need for additional hardware expenses or revalidation of the system.

This article introducesDionex binary ternary liquid chromatographyParallel configuration mode (including one six way valve), two UV detectors, automatic control of chromatographic valve switching time and injection program through chameleon software, and non-interference in data acquisition and processing. This article analyzes both dechlorinated hydroxyzine hydrochloride and promethazine hydrochloride simultaneously. The chromatographic analysis method and conditions are carried out in accordance with the Pharmacopoeia 2010 edition (Part 2).