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E-mail
Judy@nexstarbio.com
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Phone
17384530128
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Address
1-2F, Building 4, 1628 Lizheng Road, Lingang New Area, China (Shanghai) Pilot Free Trade Zone
Video
Nazida (Shanghai) Nanotechnology Co., Ltd
Micro flow control backup device usage tutorial
12.06,20220
Brief Introduction
Microfluidic technology:
Microfluidic technology is a technique based on (micro) fluid mechanics theory that enables sample preparation and processing in pipelines. Combining the physical and chemical models of microfluidics with fluid mechanics theory can achieve functions such as mixing, emulsification, separation, and purification of samples.
Microfluidic technology combines Process Control Technology (PCT) with Process Analytical Technology (PAT) to achieve excellent Online Preparation Technology (OPT) for sample preparation. During the continuous preparation process, the parameters of the sample are controllable and have good reproducibility, making it more scalable compared to traditional stepwise and batch production methods.
It can achieve functions such as initial emulsification, re emulsification, and particle size control of the sample.
The microfluidic control preparation system is connected to the microfluidic chip through a preparation pump and a high-pressure delivery pump. Phase A and phase B can be delivered to the chip at a constant speed in a certain proportion for mixing and emulsification. By designing different flow channel structures and controlling different speeds in microfluidic chips, the sample can achieve turbulent, laminar, or atomized states in the microfluidic chip, which can meet the requirements of sample colostrum or re emulsification.
The prepared sample is transported to a high-pressure microfluidic chip through a high-pressure pump, and the particle size is controlled by impact and shear forces to achieve the desired range. The minimum particle size can reach within 100nm, and the PDI is below 0.1.
The prepared sample is transported to a high-pressure microfluidic chip through a high-pressure pump, and the particle size is controlled by impact and shear forces to achieve the desired range. The minimum particle size can reach within 100nm, and the PDI is below 0.1.
Microfluidic chip:
Microfluidic chip, also known as Lab-on-a-Chip, is a scientific technology characterized by manipulating fluids in micro nano scale spaces. It has the ability to miniaturize basic functions of biological, chemical, and other laboratories such as sample preparation, reaction, separation, and detection onto a few square centimeter chip. Its basic features andIt is a flexible combination and scale integration of multiple unit technologies on a controllable micro platform.
Technical Specifications:
Product advantages:1. The performance is comparable to imported products, and the price is less than one-fifth of imported products
2. The dead volume is small, less than 0.05ml, with no official connection in the middle. The part in contact with the liquid is a disposable syringe and 316L stainless steel chip, which can be steam sterilized
3.316L stainless steel chip has no limit on usage times, no consumable cost, and can withstand organic solvents such as chloroform
4. The chip interface withstand voltage is 0.7Mpa, ensuring no material leakage during use
5. It has a heating function, which can be used for mRNA LNP encapsulation or liposome encapsulation, and can be heated above the phospholipid phase transition temperature
6. The device has a small size and can be operated in a biosafety cabinet to avoid contamination
Microfluidic Control Preparation Instrument/LNP Preparation/mRNA Loading Microfluidic Control Preparation Instrument/LNP Preparation/mRNA Loading
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