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How can nanomanipulation machines achieve precise manipulation of atoms and molecules?
Date: 2025-11-12Read: 0

In the microscopic world, atoms and molecules are the basic units that make up matter, and nanomanipulation machines are like "microscopic hands" that achieve precise manipulation of them, bringing revolutionary breakthroughs to fields such as materials science and biomedicine. So, how does the nanomanipulator achieve this? ​

The precision manipulation of atoms and molecules by nanomanipulation machines relies on the use of special physical effects and precise control technologies to break through the limitations of macroscopic operations and perform operations at the nanoscale or even atomic scale. The key principle is to utilize the interaction forces between atoms, such as van der Waals forces, electrostatic forces, and advanced detection and feedback mechanisms, to ensure that every step of the operation is precise and error free. ​
From a specific technical perspective, scanning tunneling microscopy (STM) technology is one of the important means. The tip of STM is extremely sharp, consisting only of a few or even one atom. When the needle tip is in close proximity (usually at the nanometer level) to the surface of the manipulated atom or molecule, tunneling current is generated. By precisely controlling the distance between the needle tip and the sample surface, and utilizing the van der Waals force or electrostatic force between the needle tip and atoms, atoms can be "grasped" or "moved". For example, scientists once used STM technology to move xenon atoms one by one on the surface of copper, arranging the three letters "IBM" to visually demonstrate precise manipulation at the atomic level. ​
Atomic force microscopy (AFM) technology is another commonly used method. AFM obtains surface morphology information and achieves manipulation by detecting the interaction forces between the needle tip and the surface atoms of the sample. Unlike STM, AFM can not only work on conductive samples, but also on insulating samples. During the manipulation process, the AFM tip contacts or approaches the atoms, and by controlling the magnitude and direction of the force exerted by the tip, pushes the atoms or molecules to the designated position. For example, when constructing nanodevices, researchers use AFM to precisely place specific molecules on the substrate, laying the foundation for manufacturing high-performance nanoelectronic components. ​
In addition, optical tweezers technology also plays an important role. It utilizes the radiation pressure generated by the gradient light field formed by the laser beam to capture and manipulate tiny particles, including atoms and molecules, like tweezers. Optical tweezers have the advantage of non-contact manipulation, which can avoid physical damage to the manipulated object. In the field of biology, optical tweezers can be used to precisely manipulate biomolecules, such as studying the folding and stretching processes of DNA, helping scientists explore the mysteries of life in depth. ​
The precise manipulation of atoms and molecules by nanomanipulation machines is the result of interdisciplinary integration, involving multiple fields such as physics, materials science, and precision mechanical engineering. With the continuous advancement of technology, its manipulation accuracy and efficiency will continue to improve, and it is expected to play a more important role in fields such as quantum computing, new material preparation, and precision medicine in the future, opening up new paths for human exploration of the microscopic world and promoting technological development.