-
E-mail
inquiry@synvol.com
-
Phone
13851985276
-
Address
No. 2 Jinyuan Road, Jiangning District, Nanjing City
Nanjing Sivo Biotechnology Co., Ltd
The influence and control method of high-speed centrifugal screen speed on brittle particle damage rate
Date: 2025-11-14Read: 1
High speed centrifugal sieveWidely used for rapid grading of pharmaceutical particles, but its high rotational speed (usually 1500-3000 rpm) brings strong centrifugal force and particle collision, which can easily cause brittle particles (such as those containing inorganic salts, high drug loading, or low binder formulations) to break, increase the fine powder rate, and affect the quality of subsequent tablets. Therefore, it is crucial to clarify the relationship between rotational speed and damage rate and develop control strategies.
Experiments have shown that there is a non-linear positive correlation between particle breakage rate and rotational speed. Taking a certain calcium tablet particle as an example, the damage rate is about 2.1% at 1500 rpm; When it reaches 2500 rpm, the damage rate suddenly increases to 8.7%; After exceeding 2800 rpm, the wear of the screen mesh intensifies and the risk of debris entering the product increases. The fundamental reason is that at high speeds, the kinetic energy of particles hitting the sieve increases, and at the same time, the number of cycles of particles in the sieve chamber increases, leading to the accumulation of multiple impacts and structural failure.
To control damage, the following measures can be taken:
Optimize the speed window: Determine the "critical speed" through small-scale experiments - that is, the lower speed that meets the screening efficiency premise;
Improve the material and structure of the mesh: use polyurethane coated mesh or laser cut mesh with higher porosity to reduce impact rigidity;
Adjust feed rate and distribution: evenly distribute fabric to reduce local accumulation and avoid particle avalanche impact;
Introducing buffer deflectors: Install arc-shaped baffles inside the screening chamber to guide particles to smoothly slide and reduce rebound collisions.
A certain enterprise willHigh speed centrifugal sieveAfter reducing the speed from 2600 rpm to 2100 rpm and using a polyurethane sieve, the brittle particle breakage rate remained stable at below 3%, while the screening efficiency remained above 95%. Practice has proven that "moderate deceleration+flexible contact" is an effective path to balance efficiency and integrity.