In the pharmaceutical process, 80% of the active ingredients in drugs exist in crystalline form, while 40% of the industrial pharmaceutical crystallization process uses cooling crystallization. This crystallization method has become an important means of purification and separation in the pharmaceutical industry. In addition, the crystallization process determines the purity and properties of the crystals, and interacts with the bioavailability, stability, release performance, compression performance, quality controllability, clinical efficacy, and safety of drugs. It can be seen that drug crystallization plays an important role in the drug production process, and therefore pharmaceutical companies are willing to invest more resources in this area of technology.

With the continuous innovation and development of science and technology, a series of high-tech have been applied in the research of drug crystallization, which helps to improve the efficiency of drug crystallization and the controllability of production processes.

Technobis' advanced crystallization system has been widely used by pharmaceutical companies for many years. After 17 years, it has over 600 users worldwide and is applied in major research laboratories, allowing researchers to easily visualize, understand, and monitor the crystallization process, improving and accelerating crystallization research.

As a supplier of crystallization system technology, Technobis has always pursued technological advancement and continuously improved its products. In recent years, its Crystal16 and Crystaline have also been successfully upgraded to further improve the efficiency and quality of crystallization research with more advanced technology. This time we will introduce the advantages of the all-new upgraded version of Crystal16 V3 to everyone.

The Crystal16 crystallization system can be used for the formation of polymorphs, salts, or eutectics. This lightweight instrument uses 16 parallel reactors and can test various crystallization conditions, such as solvents and solvent mixtures, compound concentrations, counterions, and temperature curves. Crystal16 combines automation with transparency technology, allowing researchers to easily determine inventory and cloud point, thereby obtaining solubility data and mg/ml metastable zone width (MSZW) in the early stages. In the experiment, less than 100mg of sample was needed to quickly construct solubility curves for four different dissolution systems within four hours.

The all-new upgrade of Crystal16 V3 not only implements the integrated design to improve equipment maintenance and reliability, but also has various performance improvements:

Advanced temperature control technology

Lower crystallization cooling temperature

Crystal16 V3 has improved thermal stability and measurement range, integrating air cooling function. It can now use air cooling on four reactor blocks simultaneously to achieve temperature control up to -20 ° C, allowing the temperature range to reach -20 to 150 ° C. If an external cooler is selected, the performance can be further improved, and crystallization research can be conducted at temperatures as low as -25 ° C.

Breakthrough transmittance technology

Stronger analytical skills

The upgraded design has also improved accuracy and enhanced analytical capabilities by improving particle detection at low and high concentrations. By increasing the detection limit in high concentration areas, it means that samples with more turbidity, darkness, and particle contamination can be measured, and even samples with two consecutive crystallization steps may be measured.

Advanced software

Integrate research and analysis functions

In the past, when conducting crystallization experiments, it was necessary to program and monitor the crystallization system, and then transmit the data to another software for data analysis. The newly designed software integrates comprehensive research and analysis functions, reducing the tedious steps of data transmission. The overall software design is also more flexible, intuitive, and convenient to operate.

Technobis' crystallization system is constantly innovating and improving to meet the new demands of researchers and the market. Its products are widely used in the fields of pharmaceuticals, agrochemicals, academic research, etc., creating more possibilities for crystallization research.

Add promotion during the same period

From October 27th to 29th, Liyang will participate in the event held in FuzhouThe 9th Annual Conference of the Chinese Crystallographic SocietyWelcome to our booth at that time to learn more about new technologies in crystallization research or contact Liyang Assistant for more information!

Booth Number: 24

Liyang Enterprise Co., Ltd

The 9th Annual Conference of the Chinese Crystallographic Society

Date:October 27-29

Location: Fujian Hall, Xihu Hotel, Fuzhou City