Chronic heart failure (CHF) is a global health challenge. High incidence rate and mortality have brought heavy burdens to countless families. Although existing drugs can alleviate symptoms to a certain extent, traditional systemic administration methods are difficult to maintain ideal concentrations at the site of cardiac lesions and are prone to side effects, limiting the breakthrough of therapeutic efficacy. Recently, a study published in the International Journal of Pharmacology has provided new ideas for solving this problem.

The research team successfully prepared mesoporous nano bioactive glass microspheres loaded with sakubatrivalsartan by the sol-gel method. Through the microscopic morphology observation of ZEM20 scanning electron microscope by Zeyou Technology, it was confirmed that the carrier has a uniform spherical structure and ideal particle size, laying the foundation for drug sustained release.

MNBG characterization. (a) Nitrogen adsorption/desorption isotherm, (b) pore size distribution curve, (c) drug release curve over time

The nitrogen adsorption experiment and in vitro release curve further showed that the carrier has a typical mesoporous structure and can achieve stable drug release within more than 500 hours, demonstrating its enormous potential as a sustained-release carrier.

In a rat model of chronic heart failure, a novel drug delivery system demonstrated therapeutic efficacy. Compared with the conventional drug group, the SVST/MNBG treatment group significantly increased the left ventricular ejection fraction and short axis shortening rate in rats, and the CK-MB and NT proBNP indicators representing myocardial injury were also significantly reduced, indicating effective improvement in cardiac function.

Cardiac function indicators of rats in each group. (a) Left ventricular end diastolic diameter (b), left ventricular end systolic diameter (c), left ventricular ejection fraction (d), left ventricular short axis shortening rate (e), left ventricular posterior wall end diastolic thickness (f), left ventricular posterior wall end systolic thickness

The pathological section results showed that the myocardial fibers of rats receiving the new treatment were arranged more orderly, with clear cell structures and almost no fiber breakage or vacuolar phenomenon, significantly better than the model group and conventional drug group.

Pathological morphology of myocardial tissue in each group of rats (× 200, × 400). (a) Control group, (b) chronic heart failure group, (c) sacubitril valsartan tablets group, (d) sacubitril valsartan tablets/mesoporous nanobioactive glass group

In depth research has shown that SVST/MNBG can exert a protective effect by regulating the balance between apoptosis and autophagy: on the one hand, it upregulates the anti apoptotic protein Bcl-2 and downregulates the pro apoptotic protein Bax; On the other hand, regulating autophagy related proteins and restoring normal cellular function.

In this study, the high-precision imaging of ZEM20 scanning electron microscope by Zeyou Technology provided important support for carrier characterization. This device combines portability and high performance, suitable for various scientific research scenarios.

This study not only provides new strategies for the treatment of heart failure, but also demonstrates the broad prospects of targeted drug delivery systems in precision medicine. With the continuous maturity of technology, it is expected to bring good news to more patients in the future.