Nimodipine is a second-generation dihydropyridine calcium ion antagonist that protects and promotes memory, as well as intellectual recovery

The function of Fu is clinically used to prevent vascular spasm after subarachnoid hemorrhage. The commercially available dosage forms include tablets, capsules, and injections

The oral bioavailability of tablets and capsules is low, with significant individual differences. Nimodipine has low solubility, and its injection contains volume fraction

Ethanol with a concentration of over 20% as a co solvent is prone to local irritation during injection, and crystals may precipitate when diluted by intravenous injection [1]. The author uses centrifugation

Using the stability constant (Ke) as an indicator, the orthogonal design method was used to screen the formulation and process of Nimodipine microemulsion for injection, with the aim of preparing a stable microemulsion

Nimodipine microemulsion for injection increases the solubility of Nimodipine, reduces toxicity and adverse reactions.

1. Instruments and Materials

LDZ5-2 low-speed automatic balancing centrifuge (Beijing Medical Centrifuge Factory), DF-101S heat collecting constant temperature heating magnetic stirrer (river)

Nangongyi Yingyu Yuhua Instrument Factory, LS230 laser particle size analyzer (Beckman Corporation, USA), COUPTER DELSA440 SXzeta electric

Position measuring instrument (Beckman, USA), DDS-11C conductivity meter (Shanghai Leici Instrument Factory),AH-100D High Pressure Homogenizer（

ATS Industrial Systems Co., Ltd， WFZ800-D2 UV Visible spectrophotometer (Beijing Second Optical Instrument Factory), SZ-96 automatic

Pure water distiller (Shanghai Yarong Biochemical Instrument Factory), DT-100A electronic balance (Shenyang Jielong Instrument Co., Ltd.), FA2104 electric

Ziping (Shanghai Precision Instrument Science Co., Ltd.), FJ-200 high-speed dispersing homogenizer (Shanghai Specimen Model Factory).

Nimodipine API (Jinan Dongfeng Pharmaceutical Factory Co., Ltd., purity mass fraction of 99.6%), injectable soybean oil (Liaoning)

Tieling North Asia Medicinal Oil Co., Ltd.), medium chain fatty acid glycerides (Miglitol 812, Liaoning Tieling North Asia Medicinal Oil Co., Ltd.),

Soy phospholipids (SPC, Shanghai Taiwei Pharmaceutical Co., Ltd.), glycerol for injection (Zhejiang Suichang Glycerol Factory), Pluronic F-68（poloxamer 188，

BASF Germany), oleic acid (Tianjin Bodi Chemical Co., Ltd.), other reagents (analytical grade, commercially available).