Folic acid is a water-soluble B vitamin that participates in multiple physiological activities in the human body and has important nutritional value. It is also a basic unit for constructing functional materials. However, the photostability of folic acid limits its practical applications. Many studies have confirmed that as long as a hydrophobic space can be provided for folic acid and it can be encapsulated within it to prevent exposure to air, the photostability of folic acid can be improved to a certain extent. Surfactants are a type of carrier that can provide excellent hydrophobic space and have been widely used in pharmaceutical formulations to improve the solubility, stability, and biocompatibility of organic small molecule drugs. In addition, the addition of organic small molecules can shield the electrostatic repulsion between polar head groups of surfactants, enhance the hydrophobic interactions between alkyl chains of surfactants, resulting in lower critical micelle concentration (CMC) and higher surface activity of surfactants, further improving their ability to solubilize and encapsulate small molecular7,8. The solubilization and encapsulation of organic small molecules by surfactants are related to the molecular structure of surfactants. Therefore, selecting a surfactant protective carrier for folic acid is a meaningful work.