Parallel high-pressure reactorAs the core equipment for multi-channel synchronous reactions, it is widely used in catalysis and synthesis experiments in fields such as chemical engineering, materials, and pharmaceuticals. Scientific selection and standardized practical operation can not only ensure experimental safety and data accuracy, but also extend the service life of equipment. This article breaks down specific operational methods from two dimensions: the core points of selection and the practical process.
1、 Key points for selecting parallel high-pressure reactors
1. Clarify the reaction condition parameters
Pressure and temperature range: Based on the maximum reaction pressure and temperature of the experiment, select equipment with rated parameters 20%~30% higher than the experimental value to avoid long-term full load operation. For example, in high-temperature and high-pressure synthesis experiments, priority should be given to selecting models with a temperature resistance of ≥ 300 ℃ and a pressure resistance of ≥ 10MPa.
Characteristics of reaction medium: If the medium is a strong acid, strong alkali, or highly corrosive fluid, the material of the kettle body should be selected from Hastelloy alloy or titanium alloy; Conventional organic solvent reactions can use 316L stainless steel; For biopharmaceutical experiments that require high cleanliness, a vessel lined with polytetrafluoroethylene can be chosen.
Number and volume of channels: Micro reactors with 6/8/12 channels (single vessel volume of 10-50mL) are preferred for small-scale screening experiments; The pilot scale experiment requires equipment with larger volumes (100-500mL/kettle) to ensure seamless integration with subsequent mass production processes.
2. Pay attention to the core configuration of the device
Stirring system: For solid-liquid mixing and high viscosity reactions, magnetic coupling stirring (without leakage risk) should be selected. The type of stirring blade should be paddle, anchor or turbine according to the reaction requirements, and the recommended adjustable speed range is 0-1500r/min.
Sealing and safety devices: Double sealing structure (mechanical seal+gasket seal) must be equipped for high-pressure working conditions; The equipment should come with an overpressure relief valve and temperature overload alarm function to prevent safety accidents.
Temperature and pressure control accuracy: Parallel experiments require high consistency, and equipment with temperature control accuracy of ± 0.5 ℃ and pressure control accuracy of ± 0.1MPa should be selected to ensure synchronous reaction conditions in each channel.
3. Adapt to laboratory supporting conditions
Installation space: Measure the size of the laboratory countertop in advance, confirm whether the length, width, and height of the equipment are suitable, and reserve ventilation and heat dissipation space.
Media supply and discharge: Check whether the equipment is compatible with the laboratory's gas pipelines (such as hydrogen and nitrogen) and waste liquid collection system to avoid subsequent modifications.
IIParallel high-pressure reactorPractical Guide
1. Preparation before the experiment
Equipment inspection: Before starting up, check whether the pressure relief valve is reset, whether the mixing blade is stuck, and whether the sealing gaskets of each channel are intact; After connecting the power, test whether the temperature and voltage control systems are displaying normally.
Medium filling: According to the experimental formula, slowly add the reaction materials into each reaction kettle, with a filling amount not exceeding 70% of the kettle volume, to prevent material expansion and overflow during the reaction process; If inert gas needs to be introduced, first perform 3 times of vacuum pumping and nitrogen replacement to eliminate the air inside the kettle.
Parameter setting: Enter the reaction temperature, pressure, stirring speed, and reaction time in the control panel, confirm that the parameters of each channel are consistent, and start the running program.
2. Experimental process operation specifications
Real time monitoring: Regularly record temperature and pressure data of each channel during the experiment. If there are abnormal fluctuations in parameters, immediately suspend operation and investigate the cause.
Avoid illegal operations: It is strictly prohibited to operate under excessive temperature and pressure; The mixing system needs to start mixing before heating up to prevent local overheating of the material; It is prohibited to remove the kettle cover or pipeline while the equipment is running.
Emergency situation handling: If an overpressure alarm occurs, immediately open the pressure relief valve and slowly release the pressure; If there is a leak, cut off the power and gas sources first, and then proceed with subsequent treatment.
3. Cleaning and maintenance after the experiment
Unloading and discharging: After the reaction is complete, wait for the kettle to cool naturally to room temperature, slowly open the pressure relief valve to relieve pressure, and then open the kettle cover to remove the reaction product; Clean up residual materials promptly after unloading.
Cleaning and maintenance: Clean the kettle body and stirring blade with clean water or a suitable solvent. After the corrosive medium reacts, it needs to be neutralized and cleaned with dilute alkali/acid. After drying, apply anti rust oil; If the sealing gasket ages, it needs to be replaced in a timely manner.
Equipment storage: Place the cleaned reaction kettle in a dry and ventilated place, disconnect the power and gas sources, and conduct regular (monthly) no-load test runs to check the operating status of each component.